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Cellosaurus G523 (CVCL_B4P6)

[Text version]
Cell line name G523
Synonyms G523NS
Accession CVCL_B4P6
Resource Identification Initiative To cite this cell line use: G523 (RRID:CVCL_B4P6)
Comments Group: Cancer stem cell line.
Omics: Genomics; ChIP-seq; CTCF.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; Chromosome conformation analysis; Hi-C.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C9AB (G523NS-Cas9)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=30995489; DOI=10.1016/j.celrep.2019.03.047
Graham MacLeod, Danielle Anne Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle M. Kushida, Helen Yu, Fiona J. Coutinho, Florence M.G. Cavalli, Ian J. Restall ...Show all 17 authors... , Xiao-Guang Hao, Traver Hart, Hema Artee Luchman, Samuel Weiss, Peter Benjamin Dirks, Stephane Angers; Show fewer authors
Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells.
Cell Rep. 27:971-986.e9(2019)

PubMed=31249064; DOI=10.1101/gr.246520.118; PMCID=PMC6673710
Michael J. Johnston, Ana Nikolic, Nicoletta Alexandra Ninkovic, Paul Guilhamon, Florence M.G. Cavalli, Steven Seaman, Franz J. Zemp, John Lee, Aly Abdelkareem, Katrina Ellestad, Alex Murison ...Show all 25 authors... , Michelle M. Kushida, Fiona J. Coutinho, Yussanne Ma, Andrew J. Mungall, Richard Moore, Marco Antonio Marra, Michael D. Taylor, Peter Benjamin Dirks, Trevor J. Pugh, Anca Sorana Morrissy, Bradley St Croix, Douglas J. Mahoney, Mathieu Lupien, Marco Gallo; Show fewer authors
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.
Genome Res. 29:1211-1222(2019)

PubMed=36989359; DOI=10.1126/sciadv.ade5321; PMCID=PMC10058241
Xian Wang, Zhe-Yuan Gong, Tian-Cong Wang, Jun-Hui Law, Xin Chen, Si-Yi Wanggou, Jin-Tian Wang, Bin-Bin Ying, Michelle A. Francisco, Wei-Fan Dong, Yi Xiong ...Show all 19 authors... , Jerry J. Fan, Graham MacLeod, Stephane Angers, Xue-Jun Li, Peter Benjamin Dirks, Xin-Yu Liu, Xi Huang, Yu Sun; Show fewer authors
Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes.
Sci. Adv. 9:eade5321.1-eade5321.14(2023)

PubMed=38089093; DOI=10.1021/acsmaterialsau.3c00029; PMCID=PMC10510514
Laura J. Smith, Arianna Skirzynska, Allysia A. Chin, Amy E. Arnold, Michelle M. Kushida, Peter Benjamin Dirks, Molly S. Shoichet;
Engineered in vitro tumor model recapitulates molecular signatures of invasion in glioblastoma.
ACS Materials Au 3:514-527(2023)

Cross-references
Encyclopedic resources Wikidata; Q110432806
Gene expression databases GEO; GSM3439929
GEO; GSM3439930
GEO; GSM3439931
GEO; GSM3439938
GEO; GSM3439939
GEO; GSM3439940
Sequence databases EGA; EGAS00001003493
EGA; EGAS00001003700
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number7