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Cellosaurus AG03141.hTERT clone 8 (CVCL_B4N4)

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Cell line name AG03141.hTERT clone 8
Synonyms AG03141B:pBABE-hTERT clone 8
Accession CVCL_B4N4
Resource Identification Initiative To cite this cell line use: AG03141.hTERT clone 8 (RRID:CVCL_B4N4)
Comments Population: Caucasian; Spanish.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:12791; WRN; Simple; p.Gln748Ter (c.2242C>T) (2476C>T); ClinVar=VCV000835212; Zygosity=Homozygous (from parent cell line).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X767 (AG03141)
Sex of cell Female
Age at sampling 29Y11M
Category Telomerase immortalized cell line
Publications

PubMed=10615119; DOI=10.1038/71630
Fiona S. Wyllie, Christopher J. Jones, Julia W. Skinner, Michele F. Haughton, Corrin Wallis, David Wynford-Thomas, Richard G.A. Faragher, David Kipling;
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.
Nat. Genet. 24:16-17(2000)

PubMed=16339323; DOI=10.1093/gerona/60.11.1386
Terence Davis, Duncan M. Baird, Michele F. Haughton, Christopher J. Jones, David Kipling;
Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.
J. Gerontol., A, Biol. Sci. Med. Sci. 60:1386-1393(2005)

Cross-references
Encyclopedic resources Wikidata; Q110432569
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number7