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Cellosaurus AG03141.hTERT clone 8 (CVCL_B4N4)

[Text version]
Cell line name AG03141.hTERT clone 8
Synonyms AG03141B:pBABE-hTERT clone 8
Accession CVCL_B4N4
Resource Identification Initiative To cite this cell line use: AG03141.hTERT clone 8 (RRID:CVCL_B4N4)
Comments Population: Caucasian; Spanish.
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 12791; WRN; Simple; p.Gln748Ter (c.2242C>T) (2476C>T); ClinVar=VCV000835212; Zygosity=Homozygous (from parent cell line).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X767 (AG03141)
Sex of cell Female
Age at sampling 29Y11M
Category Telomerase immortalized cell line

PubMed=10615119; DOI=10.1038/71630
Wyllie F.S., Jones C.J., Skinner J.W., Haughton M.F., Wallis C., Wynford-Thomas D., Faragher R.G.A., Kipling D.
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.
Nat. Genet. 24:16-17(2000)

PubMed=16339323; DOI=10.1093/gerona/60.11.1386
Davis T., Baird D.M., Haughton M.F., Jones C.J., Kipling D.
Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.
J. Gerontol. 60:1386-1393(2005)

Encyclopedic resources Wikidata; Q110432569
Entry history
Entry creation16-Dec-2021
Last entry update29-Jun-2023
Version number4