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Cellosaurus AG03141 (CVCL_X767)

[Text version]
Cell line name AG03141
Synonyms AG 3141; AG3141; AG03141A; AG03141B
Accession CVCL_X767
Resource Identification Initiative To cite this cell line use: AG03141 (RRID:CVCL_X767)
Comments Population: Caucasian; Spanish.
Omics: miRNA expression profiling.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 12791; WRN; Simple; p.Gln748Ter (c.2242C>T) (2476C>T); ClinVar=VCV000835212; Zygosity=Homozygous (Coriell=AG03141).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B4N4 (AG03141.hTERT clone 8)CVCL_ZS69 (hTERT-WRN1)
Sex of cell Female
Age at sampling 29Y11M
Category Finite cell line

Coriell L.L., Greene A.E., Mulivor R.A.
The human genetic mutant cell repository: list of genetic variants, chromosomal aberrations and normal cell cultures submitted to the repository. 7th edition. October 1980.
(In) Institute for Medical Research (Camden, N.J.) NIH 80-2011; pp.1-254; National Institutes of Health; Bethesda (1980)

PubMed=7253718; DOI=10.1016/0047-6374(81)90027-0
Das N.K., Murphy D.G.
The National Institute on Aging repository cell cultures.
Mech. Ageing Dev. 16:1-17(1981)

National Institute on Aging
1994 catalog of cell lines. NIA Aging Cell Repository.
(In) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda (1994)

PubMed=10615119; DOI=10.1038/71630
Wyllie F.S., Jones C.J., Skinner J.W., Haughton M.F., Wallis C., Wynford-Thomas D., Faragher R.G.A., Kipling D.
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.
Nat. Genet. 24:16-17(2000)

PubMed=10655550; DOI=10.1093/hmg/9.3.403
Ouellette M.M., McDaniel L.D., Wright W.E., Shay J.W., Schultz R.A.
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes.
Hum. Mol. Genet. 9:403-411(2000)

PubMed=16339323; DOI=10.1093/gerona/60.11.1386
Davis T., Baird D.M., Haughton M.F., Jones C.J., Kipling D.
Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.
J. Gerontol. 60:1386-1393(2005)

PubMed=24749076; DOI=10.1016/j.stemcr.2014.02.006
Cheung H.-H., Liu X.-Z., Canterel-Thouennon L., Li L., Edmonson C., Rennert O.M.
Telomerase protects Werner syndrome lineage-specific stem cells from premature aging.
Stem Cell Reports 2:534-546(2014)

Cell line collections (Providers) Coriell; AG03141
Cell line databases/resources CLO; CLO_0036986
Encyclopedic resources Wikidata; Q54609725
Gene expression databases GEO; GSM1184266
GEO; GSM1184267
GEO; GSM1535462
GEO; GSM1535470
Entry history
Entry creation05-Sep-2014
Last entry update30-Jan-2024
Version number15