ID   AG03141.hTERT clone 8
AC   CVCL_B4N4
SY   AG03141B:pBABE-hTERT clone 8
DR   Wikidata; Q110432569
RX   PubMed=10615119;
RX   PubMed=16339323;
CC   Population: Caucasian; Spanish.
CC   Sequence variation: Mutation; HGNC; 12791; WRN; Simple; p.Gln748Ter (c.2242C>T) (2476C>T); ClinVar=VCV000835212; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 11730; TERT.
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C3447; Werner syndrome
DI   ORDO; Orphanet_902; Werner syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X767 ! AG03141
SX   Female
AG   29Y11M
CA   Telomerase immortalized cell line
DT   Created: 16-12-21; Last updated: 29-06-23; Version: 4
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RX   PubMed=10615119; DOI=10.1038/71630;
RA   Wyllie F.S., Jones C.J., Skinner J.W., Haughton M.F., Wallis C.,
RA   Wynford-Thomas D., Faragher R.G.A., Kipling D.;
RT   "Telomerase prevents the accelerated cell ageing of Werner syndrome
RT   fibroblasts.";
RL   Nat. Genet. 24:16-17(2000).
//
RX   PubMed=16339323; DOI=10.1093/gerona/60.11.1386;
RA   Davis T., Baird D.M., Haughton M.F., Jones C.J., Kipling D.;
RT   "Prevention of accelerated cell aging in Werner syndrome using a p38
RT   mitogen-activated protein kinase inhibitor.";
RL   J. Gerontol. 60:1386-1393(2005).
//