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Cellosaurus IGR-39D (CVCL_B491)

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Cell line name IGR-39D
Synonyms IGR 39D; IGR39D
Accession CVCL_B491
Resource Identification Initiative To cite this cell line use: IGR-39D (RRID:CVCL_B491)
Comments Population: Caucasian.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys229Tyrfs*10 (c.686_687delGT); ClinVar=VCV000863486; Zygosity=Unspecified (PubMed=10070891).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2076 (IGR-39)
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
Publications

PubMed=3402430; DOI=10.1002/j.1460-2075.1988.tb02909.x; PMCID=PMC454430
Rogier Versteeg, Inge A. Noordermeer, Margreet Kruse-Wolters, Dirk J. Ruiter, Peter I. Schrier;
c-myc down-regulates class I HLA expression in human melanomas.
EMBO J. 7:1023-1029(1988)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648
Shuraila Francisca Zerp, Andrea van Elsas, Lucy T.C. Peltenburg, Peter I. Schrier;
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B491
Encyclopedic resources Wikidata; Q54897369
Polymorphism and mutation databases Cosmic; 1418459
IARC_TP53; 10955
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number18