ID   IGR-39D
AC   CVCL_B491
SY   IGR 39D; IGR39D
DR   cancercelllines; CVCL_B491
DR   Cosmic; 1418459
DR   IARC_TP53; 10955
DR   Wikidata; Q54897369
RX   PubMed=3402430;
RX   PubMed=10070891;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys229Tyrfs*10 (c.686_687delGT); ClinVar=VCV000863486; Zygosity=Unspecified (PubMed=10070891).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2076 ! IGR-39
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 17
//
RX   PubMed=3402430; DOI=10.1002/j.1460-2075.1988.tb02909.x;
RA   Versteeg R., Noordermeer I.A., Kruse-Wolters M., Ruiter D.J.,
RA   Schrier P.I.;
RT   "c-myc down-regulates class I HLA expression in human melanomas.";
RL   EMBO J. 7:1023-1029(1988).
//
RX   PubMed=10070891; DOI=10.1038/sj.bjc.6690147;
RA   Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.;
RT   "p53 mutations in human cutaneous melanoma correlate with sun exposure
RT   but are not always involved in melanomagenesis.";
RL   Br. J. Cancer 79:921-926(1999).
//