| Cell line name |
IV-A1-j |
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| Synonyms |
IV-AI-j; A1-j |
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| Accession |
CVCL_B3UN |
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| Resource Identification Initiative |
To cite this cell line use: IV-A1-j (RRID:CVCL_B3UN) |
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| Comments |
Characteristics: Resistant to an insulin-diphtheria-A chain toxic conjugate (DTaI).
Selected for resistance to: Diphtheria A chain:insulin (DTaI).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553. |
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| Sequence variations |
- Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
- Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
|
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| Species of origin |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
(NCBI Taxonomy: 10029) |
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| Hierarchy |
Parent: CVCL_2234 (V79) |
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| Sex of cell |
Male |
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| Age at sampling |
Adult |
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| Category |
Spontaneously immortalized cell line |
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| Publications | CLPUB00663
Blaine Leckett;
The selection, isolation, and characterization of a Chinese hamster lung fibroblast cell line resistant to an insulin-diphteria A-chain toxic conjugate molecule.
Thesis PhD (1992); McGill University Montreal; Montreal; Canada PubMed=1369208; DOI=10.1007/BF00570889
Blaine Leckett, Ralph Joseph Germinario;
Construction of a toxic insulin molecule: selection and partial characterization of cells resistant to its killing effects.
Cytotechnology 10:125-136(1992) PubMed=8468364; DOI=10.1002/jcp.1041550123
Blaine Leckett, Aleksandrs Spurmanis, Cynthia Allen, Ralph Joseph Germinario;
Mutant cell line demonstrating a block in insulin and insulin-like growth factor type 1 (IGF-1) induced mitogenesis.
J. Cell. Physiol. 155:179-184(1993) CLPUB00664
Aleksandrs Spurmanis;
Characterization of a mutant Chinese hamster fibroblast line resistant to the mitogenic effects of insulin.
Thesis MSc (1996); Concordia University; Montreal; Canada |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q110432990
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| Entry history |
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| Entry creation | 16-Dec-2021 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 5 |
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