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Cellosaurus 4T1.3 (CVCL_B3QZ)

[Text version]
Cell line name 4T1.3
Accession CVCL_B3QZ
Resource Identification Initiative To cite this cell line use: 4T1.3 (RRID:CVCL_B3QZ)
Comments Characteristics: Metastasizes with high frequency to bone upon orthotopic injection into the mammary fat pad of immunocompetent female BALB/c mice (PubMed=27177471).
Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
Hierarchy Parent: CVCL_0125 (4T1)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=27177471; DOI=10.1016/j.canlet.2016.05.005
So-ichiro Sasaki, Tomohisa Baba, Tatsunori Nishimura, Yoshihiro Hayakawa, Shin-ichi Hashimoto, Noriko Gotoh, Naofumi Mukaida;
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.
Cancer Lett. 378:23-32(2016)

PubMed=34632664; DOI=10.1111/cas.15150; PMCID=PMC8645723
So-ichiro Sasaki, Di Zhang, Sadahiro Iwabuchi, Yamato Tanabe, Shin-ichi Hashimoto, Akira Yamauchi, Katsuhiro Hayashi, Hiroyuki Tsuchiya, Yoshihiro Hayakawa, Tomohisa Baba, Naofumi Mukaida;
Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
Cancer Sci. 112:4883-4893(2021)

Cross-references
Encyclopedic resources Wikidata; Q110429789
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number6