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Cellosaurus PC3-epi (CVCL_B0CB)

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Cell line name PC3-epi
Synonyms PC3-Epi
Accession CVCL_B0CB
Resource Identification Initiative To cite this cell line use: PC3-epi (RRID:CVCL_B0CB)
Comments Population: Caucasian.
Characteristics: Selected based on an epithelial cell morphology, bioluminescent intensity and expression of E-cadherin. Selection was repeated twice and a stable epithelial population was obtained (PubMed=24124593).
Characteristics: Transfected with a pLentilox-EV-Luc luciferase expression vector.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Children:
CVCL_B0CN (PC3-EMT1)CVCL_B0E4 (PC3-EMT12)CVCL_B0E3 (PC3-EMT14)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=24124593; DOI=10.1371/journal.pone.0076773; PMCID=PMC3790720
Hernan Roca, James R. Hernandez, Savannah Weidner, Richard C. McEachin, David Fuller, Sudha Sud, Taibriana Schumann, John E. Wilkinson, Alexander Zaslavsky, Hang-Wen Li, Christopher A. Maher ...Show all 14 authors... , Stephanie Daignault-Newton, Patrick N. Healy, Kenneth James Pienta; Show fewer authors
Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer.
PLoS ONE 8:e76773.1-e76773.20(2013)

PubMed=25426557; DOI=10.18632/oncotarget.2766; PMCID=PMC4381583
Takumi Shiraishi, James E. Verdone, Jessie Huang, Ulf Dietrich Kahlert, James R. Hernandez, Gonzalo Torga, Jelani Chinelo Zarif, Tamir Epstein, Robert Gatenby, Annemarie McCartney, Jennifer Hartt Elisseeff ...Show all 14 authors... , Steven M. Mooney, Steven S. An, Kenneth James Pienta; Show fewer authors
Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells.
Oncotarget 6:130-143(2015)

Cross-references
Cell line collections (Providers) ATCC; CRL-3470
Cell line databases/resources cancercelllines; CVCL_B0CB
Encyclopedic resources Wikidata; Q108821094
Gene expression databases GEO; GSM1063981
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number9