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Cellosaurus KRIB (CVCL_AU05)

[Text version]
Cell line name KRIB
Synonyms Krib
Accession CVCL_AU05
Resource Identification Initiative To cite this cell line use: KRIB (RRID:CVCL_AU05)
Comments Population: Caucasian.
Transfected with: UniProtKB; P01117; Kirsten murine sarcoma virus Ki-Ras.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0439 (MNNG/HOS Cl #5)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line

Samid D., Mandler R.
Human osteosarcoma cells transformed by ras-oncogenes: a new model for in vivo studies of pulmonary metastasis.
Clin. Biotechnol. 1:21-26(1989)

Berlin O., Samid D., Donthineni-Rao R., Akeson W.H., Amiel D., Woods V.L. Jr.
Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice.
Cancer Res. 53:4890-4895(1993)

PubMed=22075555; DOI=10.1158/0008-5472.CAN-11-2778
Huang G.-X., Yu L., Cooper L.J.N., Hollomon M., Huls H., Kleinerman E.S.
Genetically modified T cells targeting interleukin-11 receptor alpha-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases.
Cancer Res. 72:271-281(2012)

PubMed=24136885; DOI=10.1002/pbc.24801
Guma S.R., Lee D.A., Yu L., Gordon N., Hughes D., Stewart J., Wang W.-L., Kleinerman E.S.
Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.
Pediatr. Blood Cancer 61:618-626(2014)

PubMed=26320182; DOI=10.18632/oncotarget.5177
Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P.S., Khanna C.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

Cell line databases/resources cancercelllines; CVCL_AU05
Anatomy/cell type resources BTO; BTO:0006034
Encyclopedic resources Wikidata; Q54900481
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number14