• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
  

CLPUB00319
Dvorit Samid, Raya Mandler;
Human osteosarcoma cells transformed by ras-oncogenes: a new model for in vivo studies of pulmonary metastasis.
Clin. Biotechnol. 1:21-26(1989)

PubMed=8402677
Orjan Berlin, Dvorit Samid, Rakesh Donthineni-Rao, Wayne Henry Akeson, David Amiel, Virgil Leroy Woods Jr.;
Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice.
Cancer Res. 53:4890-4895(1993)

PubMed=22075555; DOI=10.1158/0008-5472.CAN-11-2778; PMCID=PMC3833671
Gang-Xiong Huang, Ling Yu, Laurence J.N. Cooper, Mario Hollomon, Helen Huls, Eugenie S. Kleinerman;
Genetically modified T cells targeting interleukin-11 receptor alpha-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases.
Cancer Res. 72:271-281(2012)

PubMed=24136885; DOI=10.1002/pbc.24801; PMCID=PMC4154381
Sergei R. Guma, Dean Anthony Lee, Ling Yu, Nancy Gordon, Dennis Patrick Meehan Hughes, John Stewart, Wei-Lien Wang, Eugenie S. Kleinerman;
Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.
Pediatr. Blood Cancer 61:618-626(2014)

PubMed=26320182; DOI=10.18632/oncotarget.5177; PMCID=PMC4745740
Ling Ren, Arnulfo Mendoza, Jack Zhu, Joseph W. Briggs, Charles Halsey, Ellen S. Hong, Sandra Sczerba Burkett, James J. Morrow, Michael M. Lizardo, Tanasa Osborne, Samuel Q. Li ...Show all 14 authors... , Hue H. Luu, Paul S. Meltzer, Chand Khanna; Show fewer authors
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)