ID   KRIB
AC   CVCL_AU05
SY   Krib
DR   BTO; BTO:0006034
DR   cancercelllines; CVCL_AU05
DR   Wikidata; Q54900481
RX   CelloPub=CLPUB00319;
RX   PubMed=8402677;
RX   PubMed=22075555;
RX   PubMed=24136885;
RX   PubMed=26320182;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P01117; Kirsten murine sarcoma virus Ki-Ras.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0439 ! MNNG/HOS Cl #5
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 05-10-23; Version: 14
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RX   CelloPub=CLPUB00319;
RA   Samid D., Mandler R.;
RT   "Human osteosarcoma cells transformed by ras-oncogenes: a new model for
RT   in vivo studies of pulmonary metastasis.";
RL   Clin. Biotechnol. 1:21-26(1989).
//
RX   PubMed=8402677;
RA   Berlin O., Samid D., Donthineni-Rao R., Akeson W.H., Amiel D.,
RA   Woods V.L. Jr.;
RT   "Development of a novel spontaneous metastasis model of human
RT   osteosarcoma transplanted orthotopically into bone of athymic mice.";
RL   Cancer Res. 53:4890-4895(1993).
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RX   PubMed=22075555; DOI=10.1158/0008-5472.CAN-11-2778;
RA   Huang G.-X., Yu L., Cooper L.J.N., Hollomon M., Huls H., Kleinerman E.S.;
RT   "Genetically modified T cells targeting interleukin-11 receptor
RT   alpha-chain kill human osteosarcoma cells and induce the regression of
RT   established osteosarcoma lung metastases.";
RL   Cancer Res. 72:271-281(2012).
//
RX   PubMed=24136885; DOI=10.1002/pbc.24801;
RA   Guma S.R., Lee D.A., Yu L., Gordon N., Hughes D., Stewart J.,
RA   Wang W.-L., Kleinerman E.S.;
RT   "Natural killer cell therapy and aerosol interleukin-2 for the
RT   treatment of osteosarcoma lung metastasis.";
RL   Pediatr. Blood Cancer 61:618-626(2014).
//
RX   PubMed=26320182; DOI=10.18632/oncotarget.5177;
RA   Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S.,
RA   Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q.,
RA   Luu H.H., Meltzer P.S., Khanna C.;
RT   "Characterization of the metastatic phenotype of a panel of
RT   established osteosarcoma cells.";
RL   Oncotarget 6:29469-29481(2015).
//