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Cellosaurus KPC3 (CVCL_A9ZK)

[Text version]
Cell line name KPC3
Accession CVCL_A9ZK
Resource Identification Initiative To cite this cell line use: KPC3 (RRID:CVCL_A9ZK)
Comments Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
  • Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease Mouse pancreatic neoplasm (NCIt: C34035)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LSL-KrasG12D:LSL-Trp53R270H:Pdx1-Cre (KPC).
Hierarchy Children:
CVCL_A9ZL (KPC3-TRP1)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=30381448; DOI=10.1158/1535-7163.MCT-18-0679
Hreinn Benonisson, Isil Altintas, Marjolein Sluijter, Sandra Verploegen, Aran F. Labrijn, Danita H. Schuurhuis, Mischa A. Houtkamp, J. Sjef Verbeek, Janine Schuurman, Thorbald van Hall;
CD3-bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory.
Mol. Cancer Ther. 18:312-322(2019)

PubMed=32690771; DOI=10.1136/jitc-2020-000772; PMCID=PMC7373331
Sai Ping Lau, Nadine van Montfoort, Priscilla Kinderman, Melanie Lukkes, Larissa Klaase, Menno van Nimwegen, Mandy van Gulijk, Jasper Dumas, Dana A.M. Mustafa, Sanne L.A. Lievense, Christianne Groeneveldt ...Show all 21 authors... , Ralph Stadhouders, Yun-Lei Li, Andrew Stubbs, Koen A. Marijt, Heleen Vroman, Sjoerd H. van der Burg, Joachim Aerts, Thorbald van Hall, Floris Dammeijer, Casper H.J. van Eijck; Show fewer authors
Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model.
J. Immunother. Cancer 8:e000772.1-e000772.14(2020)

Cross-references
Encyclopedic resources Wikidata; Q102114430
Entry history
Entry creation29-Oct-2020
Last entry update14-Aug-2025
Version number6