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Cellosaurus KPC3-TRP1 (CVCL_A9ZL)

[Text version]
Cell line name KPC3-TRP1
Accession CVCL_A9ZL
Resource Identification Initiative To cite this cell line use: KPC3-TRP1 (RRID:CVCL_A9ZL)
Comments Genetic integration: Method=Transfection; Gene=MGI; MGI:98881; Tyrp1 (Note=With p.Gln512_Val537del).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
  • Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease Mouse pancreatic neoplasm (NCIt: C34035)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: LSL-KrasG12D:LSL-Trp53R270H:Pdx1-Cre (KPC).
Hierarchy Parent: CVCL_A9ZK (KPC3)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=30381448; DOI=10.1158/1535-7163.MCT-18-0679
Hreinn Benonisson, Isil Altintas, Marjolein Sluijter, Sandra Verploegen, Aran F. Labrijn, Danita H. Schuurhuis, Mischa A. Houtkamp, J. Sjef Verbeek, Janine Schuurman, Thorbald van Hall;
CD3-bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory.
Mol. Cancer Ther. 18:312-322(2019)

Cross-references
Encyclopedic resources Wikidata; Q102114432
Entry history
Entry creation29-Oct-2020
Last entry update14-Aug-2025
Version number6