Cellosaurus cell line Wilms1-2l (CVCL

Cellosaurus Wilms1-2l (CVCL_A5SC)

[Text version]

Cell line name

Wilms1-2l

Synonyms

Wilms1

Accession

CVCL_A5SC

Resource Identification Initiative

To cite this cell line use: Wilms1-2l (RRID:CVCL_A5SC)

Comments

Population: Caucasian.
Donor information: Established from the left kidney of the recurrence (2nd tumor) of the patient.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser50Ter (c.149C>A); Zygosity=Homozygous (PubMed=20106868; PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_A5SN (imWilms1)

Originate from same individual

CVCL_A5SD ! Wilms1-2r

Sex of cell

Female

Age at sampling

Category

Finite cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X
CSF1PO	10,12
D3S1358	14,17
D5S818	12,13
D7S820	9,14
D8S1179	12,14
D13S317	11,13
D16S539	11,14
D18S51	15,18
D21S11	30,31
FGA	22,25
Penta D	13
Penta E	5,14
TH01	9.3
TPOX	8,9
vWA	14,19

Publications

PubMed=17551084; DOI=10.1136/jmg.2006.047530; PMCID=PMC2740887
Constanze Duhme, Noelia Perez, Carmen de Torres, Maike Anna Busch, Jaume Mora, Brigitte Royer-Pokora;
Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation.
J. Med. Genet. 44:393-396(2007)

PubMed=20106868; DOI=10.1093/hmg/ddq042
Brigitte Royer-Pokora, Maike Anna Busch, Manfred Beier, Constanze Duhme, Carmen de Torres, Jaume Mora, Artur Brandt, Hans-Dieter Royer;
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Cell line collections (Providers)

CLS; 300411

Encyclopedic resources

Wikidata; Q107117461

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number