Cellosaurus cell line Wilms1-2r (CVCL

Cellosaurus Wilms1-2r (CVCL_A5SD)

Cross-references
Cell line name	Wilms1-2r
Accession	CVCL_A5SD
Resource Identification Initiative	To cite this cell line use: Wilms1-2r (RRID:CVCL_A5SD)
Comments	Population: Caucasian. Donor information: Established from the right kidney of the recurrence (2nd tumor) of the patient. Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations	Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Cys (c.134C>G); ClinVar=VCV000376242; Zygosity=Heterozygous (PubMed=33379206). Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser50Ter (c.149C>A); Zygosity=Homozygous (PubMed=33379206).
Disease	Kidney Wilms tumor (NCIt: C40407) Nephroblastoma (ORDO: Orphanet_654)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A5SC ! Wilms1-2l
Sex of cell	Female
Age at sampling	2Y
Category	Finite cell line
Publications	PubMed=17551084; DOI=10.1136/jmg.2006.047530; PMCID=PMC2740887 Constanze Duhme, Noelia Perez, Carmen de Torres, Maike Anna Busch, Jaume Mora, Brigitte Royer-Pokora; Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation. J. Med. Genet. 44:393-396(2007) PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943 Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora; Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations. Cancers (Basel) 13:60.1-60.21(2021)
Encyclopedic resources	Wikidata; Q107117463
Entry history
Entry creation	20-May-2021
Last entry update	19-Dec-2024
Version number	6