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Cellosaurus Trpl17 (CVCL_A4QV)

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Cell line name Trpl17
Synonyms SUSMi005-A
Accession CVCL_A4QV
Resource Identification Initiative To cite this cell line use: Trpl17 (RRID:CVCL_A4QV)
Comments Population: Caucasian.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Gene amplification; HGNC; HGNC:11138; SNCA; Triplication; Zygosity=Unspecified (PubMed=22110584).
Disease Parkinson disease 4, autosomal dominant (NCIt: C198604)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C0GS (SUSMi005-A-1.1)CVCL_C0GT (SUSMi005-A-1.2)CVCL_C0GU (SUSMi005-A-2.1)
CVCL_C0GV (SUSMi005-A-2.2)CVCL_C0GW (SUSMi005-A-3.1)CVCL_C0GX (SUSMi005-A-3.2)
CVCL_C0GY (SUSMi005-A-4.1)CVCL_C0GZ (SUSMi005-A-4.2)CVCL_C0H0 (SUSMi005-A-5.1)
CVCL_C0H1 (SUSMi005-A-5.2)
Originate from same individual CVCL_A4QU ! Trpl8
CVCL_A4QW ! Trpl43
Sex of cell Male
Age at sampling 48Y
Category Induced pluripotent stem cell
Publications

PubMed=22110584; DOI=10.1371/journal.pone.0026159; PMCID=PMC3217921
Blake Byers, Branden Cord, Ha Nam Nguyen, Birgitt Schule, Lief Fenno, Patrick C. Lee, Karl Alexander Deisseroth, James William Langston, Renee A. Reijo Pera, Theo D. Palmer;
SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate alpha-synuclein and are susceptible to oxidative stress.
PLoS ONE 6:e26159.1-e26159.13(2011)

PubMed=35263701; DOI=10.1016/j.scr.2022.102733
Faria Zafar, Vasavi Nallur Srinivasaraghavan, Max Yang Chen, C. Alejandra Morato Torres, Birgitt Schule;
Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson's disease.
Stem Cell Res. 60:102733-102733(2022)

Cross-references
Cell line databases/resources hPSCreg; SUSMi005-A
SKIP; SKIP001068
Biological sample resources BioSamples; SAMEA12279542
Encyclopedic resources Wikidata; Q105511266
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7