Cellosaurus cell line SK-MEL-93 DX-5 (CVCL

Cellosaurus SK-MEL-93 DX-5 (CVCL_A433)

Cross-references
Cell line name	SK-MEL-93 DX-5
Synonyms	SK-MEL-93-DX-5; SK-MEL-93 DX5; SK-MEL-93 (DX5); DX-5; DX5; SK-MEL-93(5)
Accession	CVCL_A433
Secondary accession	CVCL_U905
Resource Identification Initiative	To cite this cell line use: SK-MEL-93 DX-5 (RRID:CVCL_A433)
Comments	From: Memorial Sloan Kettering Cancer Center; New York; USA. Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=9598804). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=9598804).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_5651 ! SK-MEL-93 DX-1 CVCL_5652 ! SK-MEL-93 DX-2 CVCL_5650 ! SK-MEL-93 DX-3 CVCL_A432 ! SK-MEL-93 DX-4 CVCL_A434 ! SK-MEL-93 DX-6 CVCL_A435 ! SK-MEL-93 DX-B
Sex of cell	Female
Age at sampling	71Y
Category	Cancer cell line
Publications	PubMed=6976407; DOI=10.1084/jem.154.6.1764; PMCID=PMC2186539 Anthony P. Albino, Kenneth Oliver Lloyd, Alan N. Houghton, Herbert Friedrich Oettgen, Lloyd John Old; Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient Implications for the study of tumor antigens. J. Exp. Med. 154:1764-1778(1981) PubMed=2886213 Nicholas C. Dracopoli, Becky Alhadeff, Alan N. Houghton, Lloyd John Old; Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma. Cancer Res. 47:3995-4000(1987) PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Amy Hsiu-Ti Lin, Isabel D.C. Markl, Jane W. Fountain; Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosomes Cancer 22:157-163(1998)
Encyclopedic resources	Wikidata; Q54954345
Polymorphism and mutation databases	Cosmic; 721819 Cosmic; 926004 Cosmic; 933123
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	14