Cellosaurus logo
expasy logo

Cellosaurus SK-MEL-93 DX-5 (CVCL_A433)

[Text version]
Cell line name SK-MEL-93 DX-5
Synonyms SK-MEL-93-DX-5; SK-MEL-93 DX5; SK-MEL-93 (DX5); DX-5; DX5; SK-MEL-93(5)
Accession CVCL_A433
Secondary accession CVCL_U905
Resource Identification Initiative To cite this cell line use: SK-MEL-93 DX-5 (RRID:CVCL_A433)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Heterozygous (PubMed=9598804).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (PubMed=9598804).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5651 ! SK-MEL-93 DX-1
CVCL_5652 ! SK-MEL-93 DX-2
CVCL_5650 ! SK-MEL-93 DX-3
CVCL_A432 ! SK-MEL-93 DX-4
CVCL_A434 ! SK-MEL-93 DX-6
CVCL_A435 ! SK-MEL-93 DX-B
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=6976407; DOI=10.1084/jem.154.6.1764
Albino A.P., Lloyd K.O., Houghton A.N., Oettgen H.F., Old L.J.
Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient Implications for the study of tumor antigens.
J. Exp. Med. 154:1764-1778(1981)

PubMed=2886213
Dracopoli N.C., Alhadeff B., Houghton A.N., Old L.J.
Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma.
Cancer Res. 47:3995-4000(1987)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Walker G.J., Flores J.F., Glendening J.M., Lin A.H.-T., Markl I.D.C., Fountain J.W.
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

Cross-references
Encyclopedic resources Wikidata; Q54954345
Polymorphism and mutation databases Cosmic; 721819
Cosmic; 926004
Cosmic; 933123
Entry history
Entry creation06-Jun-2012
Last entry update30-Jan-2024
Version number13