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Cellosaurus SK-MEL-93 DX-1 (CVCL_5651)

[Text version]
Cell line name SK-MEL-93 DX-1
Synonyms SK-MEL-93-DX-1; SK-MEL-93 DX1; SK-MEL-93 (DX1); DX-1; DX1; SK-MEL-93(1); SK-MEL-93-1; SK-MEL-93; SK-Mel-93; SK-MEL93; SKMel-93; SKMEL93; SKMel93
Accession CVCL_5651
Secondary accession CVCL_3879; CVCL_U902
Resource Identification Initiative To cite this cell line use: SK-MEL-93 DX-1 (RRID:CVCL_5651)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Derived from site: Metastatic; Left thigh, hypodermis; UBERON=UBERON_0000376+UBERON_0002072.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Heterozygous (PubMed=9598804).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (PubMed=9598804).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5652 ! SK-MEL-93 DX-2
CVCL_5650 ! SK-MEL-93 DX-3
CVCL_A432 ! SK-MEL-93 DX-4
CVCL_A433 ! SK-MEL-93 DX-5
CVCL_A434 ! SK-MEL-93 DX-6
CVCL_A435 ! SK-MEL-93 DX-B
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=6976407; DOI=10.1084/jem.154.6.1764
Albino A.P., Lloyd K.O., Houghton A.N., Oettgen H.F., Old L.J.
Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient Implications for the study of tumor antigens.
J. Exp. Med. 154:1764-1778(1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=7175440; DOI=10.1084/jem.156.6.1755
Houghton A.N., Eisinger M., Albino A.P., Cairncross J.G., Old L.J.
Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.
J. Exp. Med. 156:1755-1766(1982)

PubMed=6864164; DOI=10.1084/jem.158.1.53
Houghton A.N., Brooks H., Cote R.J., Taormina M.C., Oettgen H.F., Old L.J.
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.
J. Exp. Med. 158:53-65(1983)

PubMed=2886213
Dracopoli N.C., Alhadeff B., Houghton A.N., Old L.J.
Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma.
Cancer Res. 47:3995-4000(1987)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Walker G.J., Flores J.F., Glendening J.M., Lin A.H.-T., Markl I.D.C., Fountain J.W.
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

Cross-references
Anatomy/cell type resources BTO; BTO:0002968
Encyclopedic resources Wikidata; Q54954338
Polymorphism and mutation databases Cosmic; 721816
Cosmic; 926000
Cosmic; 933119
Cosmic; 1060426
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number16