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Cellosaurus SK-MEL-93 DX-2 (CVCL_5652)

[Text version]
Cell line name SK-MEL-93 DX-2
Synonyms SK-MEL-93-DX-2; SK-MEL-93 DX2; SK-MEL-93 (DX2); DX-2; DX2; SK-MEL-93(2); SK-MEL-93-2; DX-Mel-2
Accession CVCL_5652
Secondary accession CVCL_6062
Resource Identification Initiative To cite this cell line use: SK-MEL-93 DX-2 (RRID:CVCL_5652)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5651 ! SK-MEL-93 DX-1
CVCL_5650 ! SK-MEL-93 DX-3
CVCL_A432 ! SK-MEL-93 DX-4
CVCL_A433 ! SK-MEL-93 DX-5
CVCL_A434 ! SK-MEL-93 DX-6
CVCL_A435 ! SK-MEL-93 DX-B
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=6976407; DOI=10.1084/jem.154.6.1764; PMCID=PMC2186539
Anthony P. Albino, Kenneth Oliver Lloyd, Alan N. Houghton, Herbert Friedrich Oettgen, Lloyd John Old;
Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient Implications for the study of tumor antigens.
J. Exp. Med. 154:1764-1778(1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Marilyn S. Pollack, Socorro D. Heagney, Philip O. Livingston, Jorgen Fogh;
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=6864164; DOI=10.1084/jem.158.1.53; PMCID=PMC2187084
Alan N. Houghton, Hannah Brooks, Richard J. Cote, Michael C. Taormina, Herbert Friedrich Oettgen, Lloyd John Old;
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.
J. Exp. Med. 158:53-65(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2983346; DOI=10.1073/pnas.82.5.1470; PMCID=PMC397284
Nicholas C. Dracopoli, Alan N. Houghton, Lloyd John Old;
Loss of polymorphic restriction fragments in malignant melanoma: implications for tumor heterogeneity.
Proc. Natl. Acad. Sci. U.S.A. 82:1470-1474(1985)

PubMed=3081645; DOI=10.4049/jimmunol.136.7.2534
Mounanandham Panneerselvam, Sydney Welt, Lloyd John Old, Carl-Wilhelm Vogel;
A molecular mechanism of complement resistance of human melanoma cells.
J. Immunol. 136:2534-2541(1986)

PubMed=2886213
Nicholas C. Dracopoli, Becky Alhadeff, Alan N. Houghton, Lloyd John Old;
Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma.
Cancer Res. 47:3995-4000(1987)

PubMed=1716514
Anthony P. Albino, Brigid M. Davis, David Michael Nanus;
Induction of growth factor RNA expression in human malignant melanoma: markers of transformation.
Cancer Res. 51:4815-4820(1991)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Amy Hsiu-Ti Lin, Isabel D.C. Markl, Jane W. Fountain;
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

Cross-references
Encyclopedic resources Wikidata; Q54954340
Polymorphism and mutation databases Cosmic; 721817
Cosmic; 926001
Cosmic; 933120
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number17