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Cellosaurus MDCK-hMDR1 cMDR1-KO (CVCL_A2KA)

[Text version]
Cell line name MDCK-hMDR1 cMDR1-KO
Synonyms MDCK-hMDR1cMDR1-KO
Accession CVCL_A2KA
Resource Identification Initiative To cite this cell line use: MDCK-hMDR1 cMDR1-KO (RRID:CVCL_A2KA)
Comments Knockout cell: Method=CRISPR/Cas9; VGNC; 37431; ABCB1.
Transfected with: HGNC; 40; ABCB1.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Omics: Deep quantitative proteome analysis.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_A2JZ (MDCK2-ABCB1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line

PubMed=33007277; DOI=10.1016/j.xphs.2020.09.039
Wegler C., Gazit M., Issa K., Subramaniam S., Artursson P., Karlgren M.
Expanding the efflux in vitro assay toolbox: a CRISPR-Cas9 edited MDCK cell line with human BCRP and completely lacking canine MDR1.
J. Pharm. Sci. 110:388-396(2021)

Encyclopedic resources Wikidata; Q105510097
Proteomic databases PRIDE; PXD020238
Entry history
Entry creation12-Jan-2021
Last entry update05-Oct-2023
Version number6