ID   MDCK-hMDR1 cMDR1-KO
AC   CVCL_A2KA
SY   MDCK-hMDR1cMDR1-KO
DR   PRIDE; PXD020238
DR   Wikidata; Q105510097
RX   PubMed=33007277;
CC   Knockout cell: Method=CRISPR/Cas9; VGNC; VGNC:37431; ABCB1.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:40; ABCB1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: Proteomics; Quantitative.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_A2JZ ! MDCK2-ABCB1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 12-01-21; Last updated: 10-04-25; Version: 9
//
RX   PubMed=33007277; DOI=10.1016/j.xphs.2020.09.039;
RA   Wegler, Christine
RA   Gazit, Meryem
RA   Issa, Karolina
RA   Subramaniam, Sujay
RA   Artursson, Per
RA   Karlgren, Maria
RT   "Expanding the efflux in vitro assay toolbox: a CRISPR-Cas9 edited
RT   MDCK cell line with human BCRP and completely lacking canine MDR1.";
RL   J. Pharm. Sci. 110:388-396(2021).
//