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Cellosaurus YCUB-4 (CVCL_A083)

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Cell line name YCUB-4
Synonyms YCUB4; YcuB4; Yokohama City University BCP-ALL-4
Accession CVCL_A083
Resource Identification Initiative To cite this cell line use: YCUB-4 (RRID:CVCL_A083)
Comments Population: Japanese.
Doubling time: ~48 hours (DSMZ=ACC-962).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A084 ! YCUB-4R
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-962

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133817,22
D3S135815,17
D5S81812,13
D7S82010,11
D8S117916
D13S3178
D16S5399,11
D18S5117,18
D19S43313,14
D21S1131,33.2
FGA25,26
Penta D10,11
Penta E17,21
TH017,9
TPOX8,11
vWA14,16

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Publications

PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003
Hiroaki Goto, Takuya Naruto, Reo Tanoshima, Hiromi Kato, Tomoko Yokosuka, Masakatsu Yanagimachi, Hisaki Fujii, Shumpei Yokota, Hiromi Komine;
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Leuk. Res. 33:1386-1391(2009)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=32144432; DOI=10.1007/s00280-020-04045-9
Hiroaki Goto, Yuki Yoshino, Mieko Ito, Jun-ichi Nagai, Tadashi Kumamoto, Takesi Inukai, Yukari Sakurai, Naoyuki Miyagawa, Dai Keino, Tomoko Yokosuka, Fuminori Iwasaki ...Show all 14 authors... , Satoshi Hamanoue, Masae Shiomi, Shoko Goto; Show fewer authors
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Cancer Chemother. Pharmacol. 85:773-783(2020)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Hilmar Quentmeier, Claudia Pommerenke, Hans Gunther Drexler;
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-962
Encyclopedic resources Wikidata; Q54995373
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number15