Cellosaurus cell line YCUB-4R (CVCL

Cellosaurus YCUB-4R (CVCL_A084)

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Cell line name

YCUB-4R

Synonyms

YCUB4R; Yokohama City University BCP-ALL-4 Relapse

Accession

CVCL_A084

Resource Identification Initiative

To cite this cell line use: YCUB-4R (RRID:CVCL_A084)

Comments

Population: Japanese.
Doubling time: ~48 hours (DSMZ=ACC-963).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123).
Gene fusion; HGNC; HGNC:1008; BCL9 + HGNC; HGNC:6997; MEF2D; Name(s)=MEF2D-BCL9; Note=MEF2D exon5/BCL9 exon 9 fusion (PubMed=34940123).

Disease

Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_A083 ! YCUB-4

Sex of cell

Male

Age at sampling

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-963

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D2S1338	17,22
D3S1358	15,17
D5S818	12,13
D7S820	10,11
D8S1179	16
D13S317	8
D16S539	9
D18S51	17,18
D19S433	13,14
D21S11	31,33.2
FGA	25,26
Penta D	10,11
Penta E	17,21
TH01	7
TPOX	8
vWA	14,16

Publications

PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003
Hiroaki Goto, Takuya Naruto, Reo Tanoshima, Hiromi Kato, Tomoko Yokosuka, Masakatsu Yanagimachi, Hisaki Fujii, Shumpei Yokota, Hiromi Komine;
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Leuk. Res. 33:1386-1391(2009)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Hilmar Quentmeier, Claudia Pommerenke, Hans Gunther Drexler;
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-963

Encyclopedic resources

Wikidata; Q54995374

Gene expression databases

ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039

Entry history

Entry creation

06-Jun-2012

Last entry update

10-Apr-2025

Version number