ID   YCUB-4
AC   CVCL_A083
SY   YCUB4; YcuB4; Yokohama City University BCP-ALL-4
DR   ArrayExpress; E-MTAB-11038
DR   ArrayExpress; E-MTAB-11039
DR   DSMZ; ACC-962
DR   Wikidata; Q54995373
RX   PubMed=19157546;
RX   PubMed=29786757;
RX   PubMed=32144432;
RX   PubMed=34940123;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: ~48 hours (DSMZ=ACC-962).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123).
CC   Sequence variation: Gene fusion; HGNC; HGNC:1008; BCL9 + HGNC; HGNC:6997; MEF2D; Name(s)=MEF2D-BCL9; Note=MEF2D exon5/BCL9 exon 9 fusion (PubMed=34940123).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DSMZ=ACC-962
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8
ST   D16S539: 9,11
ST   D18S51: 17,18
ST   D19S433: 13,14
ST   D21S11: 31,33.2
ST   D2S1338: 17,22
ST   D3S1358: 15,17
ST   D5S818: 12,13
ST   D7S820: 10,11
ST   D8S1179: 16
ST   FGA: 25,26
ST   Penta D: 10,11
ST   Penta E: 17,21
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 14,16
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A084 ! YCUB-4R
SX   Male
AG   7Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 15
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RX   PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003;
RA   Goto H., Naruto T., Tanoshima R., Kato H., Yokosuka T.,
RA   Yanagimachi M., Fujii H., Yokota S., Komine H.;
RT   "Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic
RT   leukemia cell lines, YCUB series, derived from children.";
RL   Leuk. Res. 33:1386-1391(2009).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=32144432; DOI=10.1007/s00280-020-04045-9;
RA   Goto H., Yoshino Y., Ito M., Nagai J.-i., Kumamoto T., Inukai T.,
RA   Sakurai Y., Miyagawa N., Keino D., Yokosuka T., Iwasaki F.,
RA   Hamanoue S., Shiomi M., Goto S.;
RT   "Aurora B kinase as a therapeutic target in acute lymphoblastic
RT   leukemia.";
RL   Cancer Chemother. Pharmacol. 85:773-783(2020).
//
RX   PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001;
RA   Quentmeier H., Pommerenke C., Drexler H.G.;
RT   "Molecular genetics of pre-B acute lymphoblastic leukemia sister cell
RT   lines during disease progression.";
RL   Curr. Issues Mol. Biol. 43:2147-2156(2021).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//