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Cellosaurus BCWM.1 (CVCL_A035)

[Text version]
Cell line name BCWM.1
Synonyms BCWM-1; BCWM_1; BCWM1; Bing Center for Waldenstrom's Macroglobulinemia.1
Accession CVCL_A035
Resource Identification Initiative To cite this cell line use: BCWM.1 (RRID:CVCL_A035)
Comments Doubling time: 3 days (PubMed=17761288).
Omics: Genomics; Whole genome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=23321251).
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VJ29 (BCWM.1/BR)CVCL_VJ30 (BCWM.1/IR)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=17761288; DOI=10.1016/j.exphem.2007.05.022
Daniel Ditzel Santos, Allen W. Ho, Olivier Tournilhac, Evdoxia Hatjiharissi, Xavier Leleu, Lian Xu, Pierfrancesco Tassone, Paola Neri, Zachary Richard Hunter, Mariana Andre Zacharias Chemaly, Andrew Robert Branagan ...Show all 24 authors... , Robert J. Manning, Christopher J. Patterson, Anne-Sophie Moreau, Bryan Ciccarelli, Sophia Adamia, Jitra Kriangkum, Jeffery L. Kutok, Yu-Tzu Tai, Jiang-Wen Zhang, Linda M. Pilarski, Kenneth Carl Anderson, Nikhil C. Munshi, Steven Peter Treon; Show fewer authors
Establishment of BCWM.1 cell line for Waldenstrom's macroglobulinemia with productive in vivo engraftment in SCID-hu mice.
Exp. Hematol. 35:1366-1375(2007)

PubMed=18650470; DOI=10.1182/blood-2008-05-154831
Peter Leif Bergsagel, Walter Michael Kuehl;
WSU-WM and BCWM.1 should not be assumed to represent Waldenstrom macroglobulinemia cell lines.
Blood 112:917-917(2008)

PubMed=22950966; DOI=10.3109/10428194.2012.727418
Hans Gunther Drexler, Su-Ning Chen, Roderick A.F. MacLeod;
Would the real Waldenstrom cell line please stand up?
Leuk. Lymphoma 54:224-226(2013)

PubMed=23321251; DOI=10.1182/blood-2012-09-454355; PMCID=PMC3596964
Lian Xu, Zachary Richard Hunter, Guang Yang, Yang-Sheng Zhou, Yang Cao, Xia Liu, Enrica Morra, Alessandra Trojani, Antonino Greco, Luca Arcaini, Marzia Varettoni ...Show all 20 authors... , Jennifer R. Brown, Yu-Tzu Tai, Kenneth Carl Anderson, Nikhil C. Munshi, Christopher J. Patterson, Robert J. Manning, Christina K. Tripsas, Neal I. Lindeman, Steven Peter Treon; Show fewer authors
MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Blood 121:2051-2058(2013)

PubMed=25382610; DOI=10.1038/bcj.2014.74; PMCID=PMC5424099
Kasyapa S. Chitta, Aneel Paulus, Thomas R. Caulfield, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Joshua Knight, Michael G. Heckman, Anthony B. Pinkerton, Asher A. Chanan-Khan;
Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia.
Blood Cancer J. 4:e260.1-e260.10(2014)

PubMed=25853860; DOI=10.1371/journal.pone.0122338; PMCID=PMC4390194
Aneel Paulus, Kasyapa S. Chitta, Paul K. Wallace, Pooja P. Advani, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Asher A. Chanan-Khan;
Immunophenotyping of Waldenstroms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications.
PLoS ONE 10:e0122338.1-e0122338.17(2015)

PubMed=28548645; DOI=10.1038/bcj.2017.40; PMCID=PMC5518884
Aneel Paulus, Sharoon Akhtar, Hafiz Muhammad Yousaf, Alak Manna, Shumail Marshal Paulus, Yamima Bashir, Thomas R. Caulfield, Maja Kristin Kuranz Blake, Kasyapa S. Chitta, Xue Wang, Yan Asmann ...Show all 15 authors... , Roman Hudec, Wolfdieter Springer, Sikander Ailawadhi, Asher A. Chanan-Khan; Show fewer authors
Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.
Blood Cancer J. 7:e565.1-e565.11(2017)

PubMed=40254718; DOI=10.1111/bjh.20072
Shi-Rong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M. Soroko, Johany Penailillo, Alexa G. Canning, Yang Cao, Guang Yang, Lian Xu, Nicholas Tsakmaklis ...Show all 22 authors... , Hao Sun, Alberto Guijosa, Maria Luisa Guerrera, Christopher J. Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, John M. Hatcher, Zachary Richard Hunter, Steven Peter Treon; Show fewer authors
Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenstrom macroglobulinaemia.
Br. J. Haematol. 206:1604-1614(2025)

Cross-references
Cell line databases/resources CLO; CLO_0009833
cancercelllines; CVCL_A035
LINCS_HMS; 51097
LINCS_LDP; LCL-2094
Anatomy/cell type resources BTO; BTO_0005177
Encyclopedic resources Wikidata; Q54795725
Polymorphism and mutation databases Cosmic; 1762456
Cosmic; 2645642
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number19