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Cellosaurus BCWM.1/BR (CVCL_VJ29)

[Text version]
Cell line name BCWM.1/BR
Synonyms BCWM1-BR; BC/BR
Accession CVCL_VJ29
Resource Identification Initiative To cite this cell line use: BCWM.1/BR (RRID:CVCL_VJ29)
Comments Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (from parent cell line).
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A035 (BCWM.1)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=25382610; DOI=10.1038/bcj.2014.74; PMCID=PMC5424099
Kasyapa S. Chitta, Aneel Paulus, Thomas R. Caulfield, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Joshua Knight, Michael G. Heckman, Anthony B. Pinkerton, Asher A. Chanan-Khan;
Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia.
Blood Cancer J. 4:e260.1-e260.10(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VJ29
Encyclopedic resources Wikidata; Q93424846
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number9