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Cellosaurus BCWM.1/IR (CVCL_VJ30)

[Text version]
Cell line name BCWM.1/IR
Synonyms BCWM_1/IR; BC/IR
Accession CVCL_VJ30
Resource Identification Initiative To cite this cell line use: BCWM.1/IR (RRID:CVCL_VJ30)
Comments Selected for resistance to: ChEBI; CHEBI:76612; Ibrutinib (Imbruvica).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (from parent cell line).
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A035 (BCWM.1)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=25382610; DOI=10.1038/bcj.2014.74
Chitta K.S., Paulus A., Caulfield T.R., Akhtar S., Blake M.-K.K., Ailawadhi S., Knight J., Heckman M.G., Pinkerton A., Chanan-Khan A.A.
Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia.
Blood Cancer J. 4:e260.1-e260.10(2014)

PubMed=28548645; DOI=10.1038/bcj.2017.40
Paulus A., Akhtar S., Yousaf H., Manna A., Paulus S.M., Bashir Y., Caulfield T.R., Kuranz-Blake M., Chitta K.S., Wang X., Asmann Y., Hudec R., Springer W., Ailawadhi S., Chanan-Khan A.A.
Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.
Blood Cancer J. 7:e565.1-e565.11(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VJ30
Encyclopedic resources Wikidata; Q93424848
Polymorphism and mutation databases Cosmic; 2645643
Entry history
Entry creation07-Sep-2018
Last entry update05-Oct-2023
Version number7