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Cellosaurus UW228 (CVCL_8585)

[Text version]
Cell line name UW228
Synonyms UW 228; HBT 228; HBT228
Accession CVCL_8585
Resource Identification Initiative To cite this cell line use: UW228 (RRID:CVCL_8585)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Sequence variations
Disease Medulloblastoma, SHH-activated, TP53-mutant (NCIt: C129442)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4460 (UW228-1)CVCL_0572 (UW228-2)CVCL_0573 (UW228-3)
Originate from same individual CVCL_DH81 ! UW402
CVCL_DH82 ! UW426
Sex of cell Female
Age at sampling 9Y
Category Cancer cell line
Publications

DOI=10.1007/0-306-46861-1_11
Francis Ali-Osman;
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10667577
Kalkunte S. Srivenugopal, Srinivas R.S. Mullapudi, Jiang Shou, Tapas K. Hazra, Francis Ali-Osman;
Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.
Cancer Res. 60:282-287(2000)

PubMed=11023825; DOI=10.1042/bj3510393; PMCID=PMC1221375
Srinivas R.S. Mullapudi, Francis Ali-Osman, Jiang Shou, Kalkunte S. Srivenugopal;
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
Biochem. J. 351:393-402(2000)

PubMed=18505928; DOI=10.1158/1541-7786.MCR-07-2105; PMCID=PMC2570202
Hui-Wen Lo, Lisa Stephenson, Xin-Yu Cao, Mira Milas, Raphael E. Pollock, Francis Ali-Osman;
Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
Mol. Cancer Res. 6:843-850(2008)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Natalia Teider, Deborah K. Scott, Adrianne Neiss, Shyamal Dilhan Weeraratne, Vladimir M. Amani, Yi-Fei Wang, Victor E. Marquez, Yoon-Jae Cho, Scott L. Pomeroy;
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuonc/noq179; PMCID=PMC3064629
Shyamal Dilhan Weeraratne, Vladimir M. Amani, Adrianne Neiss, Natalia Teider, Deborah K. Scott, Scott L. Pomeroy, Yoon-Jae Cho;
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Neuro-oncol. 13:165-175(2011)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154
Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yu-Jie Tang, Sara Bolin, Steven E. Schumacher, Rhamy Zeid, Sabran Masoud, Fu-Rong Yu ...Show all 25 authors... , Nujsaubnusi Vue, William James Gibson, Brenton R. Paolella, Siddhartha Shankar Mitra, Samuel H. Cheshier, Jun Qi, Kun-Wei Liu, Robert J. Wechsler-Reya, William Andrew Weiss, Fredrik Johansson Swartling, Mark W. Kieran, James E. Bradner, Rameen Beroukhim, Yoon-Jae Cho; Show fewer authors
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Delyan P. Ivanov, Beth Coyle, David A. Walker, Anna M. Grabowska;
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Delyan P. Ivanov, David A. Walker, Beth Coyle, Anna M. Grabowska;
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8585
Cell_Model_Passport; SIDM01399
DepMap; ACH-001232
Encyclopedic resources Wikidata; Q54992372
Gene expression databases GEO; GSM919366
Polymorphism and mutation databases IARC_TP53; 26932
Progenetix; CVCL_8585
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25