| Cell line name |
UW228-1 |
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| Accession |
CVCL_4460 |
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| Resource Identification Initiative |
To cite this cell line use: UW228-1 (RRID:CVCL_4460) |
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| Comments |
Doubling time: 25.2 +- 2.1 hours (PubMed=8866661).
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788. |
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| Sequence variations |
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Medulloblastoma, SHH-activated, TP53-mutant (NCIt: C129442)
Medulloblastoma (ORDO: Orphanet_616) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_8585 (UW228) |
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| Sex of cell |
Female |
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| Age at sampling |
9Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1292757
Guven Evren Keles, Mitchel Stuart Berger, Ramon Lim, Asgar Zaheer, Amy L. Denton, John R. Silber;
Expression of glial fibrillary acidic protein in human medulloblastoma cells treated with recombinant glia maturation factor-beta.
Oncol. Res. 4:431-437(1992) PubMed=8866661
Guven Evren Keles, Mitchel Stuart Berger, Jayashree Srinivasan, Douglas D. Kolstoe, Michael S. Bobola, John R. Silber;
Establishment and characterization of four human medulloblastoma-derived cell lines.
Oncol. Res. 7:493-503(1995) PubMed=8674085; DOI=10.1007/BF00819500
Jayashree Srinivasan, Mitchel Stuart Berger, John R. Silber;
p53 expression in four human medulloblastoma-derived cell lines.
Childs Nerv. Syst. 12:76-80(1996) PubMed=15814657; DOI=10.1158/1078-0432.CCR-04-2045
Michael S. Bobola, John R. Silber, Richard G. Ellenbogen, J. Russell Geyer, A. Blank, Ryan David Goff;
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
Clin. Cancer Res. 11:2747-2755(2005) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4460
|
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| Anatomy/cell type resources |
BTO; BTO_0004330
|
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| Encyclopedic resources |
Wikidata; Q54992373
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 22 |
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