ID   UW228-1
AC   CVCL_4460
DR   BTO; BTO_0004330
DR   cancercelllines; CVCL_4460
DR   Wikidata; Q54992373
RX   PubMed=1292757;
RX   PubMed=8674085;
RX   PubMed=8866661;
RX   PubMed=15814657;
CC   Doubling time: 25.2 +- 2.1 hours (PubMed=8866661).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
DI   NCIt; C129442; Medulloblastoma, SHH-activated, TP53-mutant
DI   ORDO; Orphanet_616; Medulloblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8585 ! UW228
SX   Female
AG   9Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
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RX   PubMed=15814657; DOI=10.1158/1078-0432.CCR-04-2045;
RA   Bobola, Michael S.
RA   Silber, John R.
RA   Ellenbogen, Richard G.
RA   Geyer, J. Russell
RA   Blank, A.
RA   Goff, Ryan David
RT   "O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and
RT   resistance to clinical alkylators in pediatric primary brain tumor
RT   cell lines.";
RL   Clin. Cancer Res. 11:2747-2755(2005).
//
RX   PubMed=8674085; DOI=10.1007/BF00819500;
RA   Srinivasan, Jayashree
RA   Berger, Mitchel Stuart
RA   Silber, John R.
RT   "p53 expression in four human medulloblastoma-derived cell lines.";
RL   Childs Nerv. Syst. 12:76-80(1996).
//
RX   PubMed=8866661;
RA   Keles, Guven Evren
RA   Berger, Mitchel Stuart
RA   Srinivasan, Jayashree
RA   Kolstoe, Douglas D.
RA   Bobola, Michael S.
RA   Silber, John R.
RT   "Establishment and characterization of four human
RT   medulloblastoma-derived cell lines.";
RL   Oncol. Res. 7:493-503(1995).
//
RX   PubMed=1292757;
RA   Keles, Guven Evren
RA   Berger, Mitchel Stuart
RA   Lim, Ramon
RA   Zaheer, Asgar
RA   Denton, Amy L.
RA   Silber, John R.
RT   "Expression of glial fibrillary acidic protein in human
RT   medulloblastoma cells treated with recombinant glia maturation
RT   factor-beta.";
RL   Oncol. Res. 4:431-437(1992).
//