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Cellosaurus SR-91 (CVCL_8441)

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Cell line name SR-91
Accession CVCL_8441
Resource Identification Initiative To cite this cell line use: SR-91 (RRID:CVCL_8441)
Comments Problematic cell line: Contaminated. Shown to be a AML-193 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 22 year old male patient with acute lymphoblastic leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00270.
Population: African American and Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+2T>G (IVS9+2T>G); ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (from parent cell line).
Disease Childhood acute myeloid leukemia (NCIt: C9160)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1071 (AML-193)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=8180609; DOI=10.3109/10428199409073789
Hans-Georg Klingemann, H.J. Gong, Guitta Maki, Douglas E. Horsman, Bakul I. Dalal, Gordon L. Phillips;
Establishment and characterization of a human leukemic cell line (SR-91) with features suggestive of early hematopoietic progenitor cell origin.
Leuk. Lymphoma 12:463-470(1994)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8441
Biological sample resources BioSample; SAMN03151611
Encyclopedic resources Wikidata; Q54955630
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27