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Cellosaurus SR-91 (CVCL_8441)

[Text version]
Cell line name SR-91
Accession CVCL_8441
Resource Identification Initiative To cite this cell line use: SR-91 (RRID:CVCL_8441)
Comments Problematic cell line: Contaminated. Shown to be a AML-193 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 22 year old male patient with acute lymphoblastic leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00270.
Population: African American and Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.993+2T>G (IVS9+2T>G); ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (from parent cell line).
Disease Childhood acute myeloid leukemia (NCIt: C9160)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1071 (AML-193)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=8180609; DOI=10.3109/10428199409073789
Klingemann H.-G., Gong H.J., Maki G., Horsman D.E., Dalal B.I., Phillips G.L.
Establishment and characterization of a human leukemic cell line (SR-91) with features suggestive of early hematopoietic progenitor cell origin.
Leuk. Lymphoma 12:463-470(1994)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line databases/resources cancercelllines; CVCL_8441
Biological sample resources BioSample; SAMN03151611
Encyclopedic resources Wikidata; Q54955630
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25