ID   SR-91
AC   CVCL_8441
DR   BioSample; SAMN03151611
DR   cancercelllines; CVCL_8441
DR   Wikidata; Q54955630
RX   PubMed=8180609;
RX   PubMed=12592342;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a AML-193 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 22 year old male patient with acute lymphoblastic leukemia.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00270.
CC   Population: African American and Caucasian.
CC   Sequence variation: Mutation; HGNC; 25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.993+2T>G (IVS9+2T>G); ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9160; Childhood acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1071 ! AML-193
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 25
RX   PubMed=8180609; DOI=10.3109/10428199409073789;
RA   Klingemann H.-G., Gong H.J., Maki G., Horsman D.E., Dalal B.I.,
RA   Phillips G.L.;
RT   "Establishment and characterization of a human leukemic cell line (SR-91)
RT   with features suggestive of early hematopoietic progenitor cell origin.";
RL   Leuk. Lymphoma 12:463-470(1994).
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).