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Cellosaurus AML-193 (CVCL_1071)

[Text version]
Cell line name AML-193
Synonyms AML193
Accession CVCL_1071
Resource Identification Initiative To cite this cell line use: AML-193 (RRID:CVCL_1071)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9589.
Population: African American and Caucasian.
Characteristics: CSF2, IL3 and IL6 dependent.
Doubling time: 65 hours (PubMed=25984343); ~50-60 hours (DSMZ=ACC-549).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (PubMed=21989985; DepMap=ACH-000557).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (PubMed=12068308; DepMap=ACH-000557).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+2T>G (IVS9+2T>G); ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (DepMap=ACH-000557).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*68:02,74:01
HLA-BB*15:10,15:10
HLA-CC*03:02,08:02
Class II
HLA-DQDQA1*04:01,05:02
DQB1*06:07,06:07
HLA-DRDRB1*12:02,13:27
Genome ancestry Source: PubMed=30894373

Origin% genome
African65.28
Native American0
East Asian, North3.56
East Asian, South0
South Asian0
European, North14.42
European, South16.74
Disease Childhood acute myeloid leukemia (NCIt: C9160)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8441 (SR-91)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-9589; DSMZ=ACC-549

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,20
D3S135816,17
D5S8189,13
D7S8209,12
D8S117913,15
D13S31712
D16S53912
D18S5113,14
D19S43314,15
D21S1130.2,31.2
FGA21,26 (ATCC=CRL-9589)
21,26.1 (DSMZ=ACC-549)
Penta D2.2,13 (ATCC=CRL-9589)
3,13 (DSMZ=ACC-549)
Penta E8,16
TH017,9
TPOX8,9
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=AML-193
Publications

PubMed=3496132; DOI=10.1182/blood.V70.1.192.192
Beverly Lange, Mauro Valtieri, Daniela Santoli, Daniele Caracciolo, Fulvio Mavilio, Ingrid Gemperlein, Constance A. Griffin, Beverly S. Emanuel, Janet Finan, Peter Carey Nowell, Giovanni Rovera;
Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.
Blood 70:192-199(1987)

PubMed=2656885; DOI=10.1002/stem.5530070202
James N. Ihle, David Askew;
Origins and properties of hematopoietic growth factor-dependent cell lines.
Int. J. Cell Cloning 7:68-91(1989)

PubMed=2015403; DOI=10.1182/blood.V77.8.1804.1804
Mauro Valtieri, Giovanni Boccoli, Ugo Testa, Cosimo Barletta, Cesare Peschle;
Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF.
Blood 77:1804-1812(1991)

PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4
Kaoru Tohyama;
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21989985; DOI=10.1182/blood-2011-05-356204; PMCID=PMC3228503
Meng Li, Roxane Collins, Yu-Chen Jiao, Peter Ouillette, Dale Bixby, Harry Erba, Bert Vogelstein, Kenneth Wayne Kinzler, Nickolas Papadopoulos, Sami N. Malek;
Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.
Blood 118:5914-5917(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-9589
ATCC; HTB-188 - Discontinued
BCRJ; 0040 - Discontinued
DSMZ; ACC-549
Cell line databases/resources CLO; CLO_0001718
CLDB; cl272
cancercelllines; CVCL_1071
CCRID; 3101HUMTCHu207
Cell_Model_Passport; SIDM01525
DepMap; ACH-000557
DSMZCellDive; ACC-549
Lonza; 1685
Anatomy/cell type resources BTO; BTO_0006203
Biological sample resources BioSample; SAMN01821616
BioSample; SAMN03471219
BioSample; SAMN10987604
Chemistry resources PharmacoDB; AML193_61_2019
Encyclopedic resources Wikidata; Q54749799
Experimental variables resources EFO; EFO_0022399
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM886867
GEO; GSM887932
Polymorphism and mutation databases Cosmic; 724816
Cosmic; 787420
Cosmic; 949089
Cosmic; 975238
Cosmic; 1012057
Cosmic; 1281305
Cosmic; 2306199
Cosmic; 2750853
IARC_TP53; 27144
LiGeA; CCLE_497
Progenetix; CVCL_1071
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number40