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Cellosaurus FL-18 (CVCL_8093)

[Text version]
Cell line name FL-18
Synonyms FL18
Accession CVCL_8093
Resource Identification Initiative To cite this cell line use: FL-18 (RRID:CVCL_8093)
Comments Population: Japanese.
Doubling time: 36-48 hours (PubMed=3928551); 25.3 hours (PubMed=8847894).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Misspelling: AKA96-3; IARC_TP53=5999; Note=Not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease Follicular lymphoma (NCIt: C3209)
Follicular lymphoma (ORDO: Orphanet_545)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_J353 ! FL-18-EB
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
Publications

PubMed=3928551; DOI=10.20772/cancersci1985.76.7_563
Hitoshi Ohno, Shoichi Doi, Shiro Fukuhara, Masaru Nishikori, Haruto Uchino, Hiroshi Fujii;
A newly established human lymphoma cell line, FL-18, carrying a 14;18 translocation.
Jpn. J. Cancer Res. 76:563-566(1985)

PubMed=2822175; DOI=10.1182/blood.V70.5.1619.1619
Shoichi Doi, Hitoshi Ohno, Eiji Tatsumi, Yuu Arita, Hiroshi Kamesaki, Shiro Fukuhara, Masaru Nishikori, Hiroshi Miwa, Kenkichi Kita, Masakazu Hatanaka, Tasuku Honjo ...Show all 13 authors... , Hiroshi Fujii, Haruto Uchino; Show fewer authors
Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line (FL-18-EB) obtained from a patient with follicular lymphoma: monoclonal derivation and different properties.
Blood 70:1619-1623(1987)

PubMed=3034807; DOI=10.1002/ijc.2910390622
Hitoshi Ohno, Shiro Fukuhara, Rei Takahashi, Koh-ichirou Mihara, Taketoshi Sugiyama, Shoichi Doi, Haruto Uchino, Kumao Toyoshima;
c-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a t(14;18) chromosomal translocation.
Int. J. Cancer 39:785-788(1987)

PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z
Jamisqn Nourse, Julia D. Mellentin, Naomi Galili, Joyce Wilkinson, Eric John Stanbridge, Stephen D. Smith, Michael L. Cleary;
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
Cell 60:535-545(1990)

PubMed=8847894
Akiyoshi Tani, Eiji Tatsumi, Fumihiko Nakamura, Shunichi Kumagai, Yoshiyuki Kosaka, Kimihiko Sano, Hajime Nakamura, Ryuichi Amakawa, Hitoshi Ohno;
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x; PMCID=PMC5921203
Takashi Akasaka, Mikiko Muramatsu, Norimitsu Kadowaki, Hitoshi Ohno, Kanji Ishizaki, Hirohiko Yamabe, Shiro Fukuhara, Minoru Okuma;
p53 mutation in B-cell lymphoid neoplasms with reference to oncogene rearrangements associated with chromosomal translocations.
Jpn. J. Cancer Res. 87:930-937(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x; PMCID=PMC11160262
Yoshitomo Maesako, Takashi Uchiyama, Hitoshi Ohno;
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=14990977; DOI=10.1038/sj.leu.2403323
Mardiah Suci Hardianti, Eiji Tatsumi, Meilani Syampurnawati, Kiyoshi Furuta, Katsuyasu Saigo, Yuji Nakamachi, Shunichi Kumagai, Hitoshi Ohno, Satoru Tanabe, M. Uchida, Norimasa Yasuda;
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.
Leukemia 18:826-831(2004)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Katsuhito Kamimura, Hiroshi Hojo, Masafumi Abe;
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Hans Gunther Drexler, Sonja Eberth, Stefan Nagel, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8093
Anatomy/cell type resources BTO; BTO_0002518
Encyclopedic resources Wikidata; Q54834952
Gene expression databases GEO; GSM3150244
Polymorphism and mutation databases Cosmic; 2396144
IARC_TP53; 5999
Proteomic databases PRIDE; PXD012087
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26