Cellosaurus logo
expasy logo

Cellosaurus FL-18 (CVCL_8093)

[Text version]
Cell line name FL-18
Synonyms FL18
Accession CVCL_8093
Resource Identification Initiative To cite this cell line use: FL-18 (RRID:CVCL_8093)
Comments Population: Japanese.
Doubling time: 36-48 hours (PubMed=3928551); 25.3 hours (PubMed=8847894).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: AKA96-3; IARC_TP53=5999; Note=Not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 990; BCL2 + HGNC; 5477; IGH; Name(s)=IGH-BCL2 (PubMed=12967475).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser127Phe (c.380C>T); ClinVar=VCV000182928; Zygosity=Unspecified (PubMed=8878455).
Disease Follicular lymphoma (NCIt: C3209)
Follicular lymphoma (ORDO: Orphanet_545)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_J353 ! FL-18-EB
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line

PubMed=3928551; DOI=10.20772/cancersci1985.76.7_563
Ohno H., Doi S., Fukuhara S., Nishikori M., Uchino H., Fujii H.
A newly established human lymphoma cell line, FL-18, carrying a 14;18 translocation.
Jpn. J. Cancer Res. 76:563-566(1985)

PubMed=2822175; DOI=10.1182/blood.V70.5.1619.1619
Doi S., Ohno H., Tatsumi E., Arita Y., Kamesaki H., Fukuhara S., Nishikori M., Miwa H., Kita K., Hatanaka M., Honjo T., Fujii H., Uchino H.
Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line (FL-18-EB) obtained from a patient with follicular lymphoma: monoclonal derivation and different properties.
Blood 70:1619-1623(1987)

PubMed=3034807; DOI=10.1002/ijc.2910390622
Ohno H., Fukuhara S., Takahashi R., Mihara K.-i., Sugiyama T., Doi S., Uchino H., Toyoshima K.
c-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a t(14;18) chromosomal translocation.
Int. J. Cancer 39:785-788(1987)

PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z
Nourse J., Mellentin J.D., Galili N., Wilkinson J., Stanbridge E.J., Smith S.D., Cleary M.L.
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
Cell 60:535-545(1990)

Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K., Nakamura H., Amakawa R., Ohno H.
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x
Akasaka T., Muramatsu M., Kadowaki N., Ohno H., Ishizaki K., Yamabe H., Fukuhara S., Okuma M.
p53 mutation in B-cell lymphoid neoplasms with reference to oncogene rearrangements associated with chromosomal translocations.
Jpn. J. Cancer Res. 87:930-937(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x
Maesako Y., Uchiyama T., Ohno H.
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=14990977; DOI=10.1038/sj.leu.2403323
Hardianti M.S., Tatsumi E., Syampurnawati M., Furuta K., Saigo K., Nakamachi Y., Kumagai S., Ohno H., Tanabe S., Uchida M., Yasuda N.
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.
Leukemia 18:826-831(2004)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Kamimura K., Hojo H., Abe M.
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

Cell line databases/resources cancercelllines; CVCL_8093
Anatomy/cell type resources BTO; BTO:0002518
Encyclopedic resources Wikidata; Q54834952
Gene expression databases GEO; GSM3150244
Polymorphism and mutation databases Cosmic; 2396144
IARC_TP53; 5999
Proteomic databases PRIDE; PXD012087
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24