ID   FL-18
AC   CVCL_8093
SY   FL18
DR   BTO; BTO:0002518
DR   cancercelllines; CVCL_8093
DR   Cosmic; 2396144
DR   GEO; GSM3150244
DR   IARC_TP53; 5999
DR   PRIDE; PXD012087
DR   Wikidata; Q54834952
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1967982;
RX   PubMed=2822175;
RX   PubMed=3034807;
RX   PubMed=3928551;
RX   PubMed=8847894;
RX   PubMed=8878455;
RX   PubMed=12967475;
RX   PubMed=14990977;
RX   PubMed=15028022;
RX   PubMed=26727417;
CC   Population: Japanese.
CC   Doubling time: 36-48 hours (PubMed=3928551); 25.3 hours (PubMed=8847894).
CC   Sequence variation: Gene fusion; HGNC; 990; BCL2 + HGNC; 5477; IGH; Name(s)=IGH-BCL2 (PubMed=12967475).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser127Phe (c.380C>T); ClinVar=VCV000182928; Zygosity=Unspecified (PubMed=8878455).
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: AKA96-3; IARC_TP53=5999; Note=Not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3209; Follicular lymphoma
DI   ORDO; Orphanet_545; Follicular lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_J353 ! FL-18-EB
SX   Male
AG   68Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
RX   PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z;
RA   Nourse J., Mellentin J.D., Galili N., Wilkinson J., Stanbridge E.J.,
RA   Smith S.D., Cleary M.L.;
RT   "Chromosomal translocation t(1;19) results in synthesis of a homeobox
RT   fusion mRNA that codes for a potential chimeric transcription
RT   factor.";
RL   Cell 60:535-545(1990).
RX   PubMed=2822175; DOI=10.1182/blood.V70.5.1619.1619;
RA   Doi S., Ohno H., Tatsumi E., Arita Y., Kamesaki H., Fukuhara S.,
RA   Nishikori M., Miwa H., Kita K., Hatanaka M., Honjo T., Fujii H.,
RA   Uchino H.;
RT   "Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line
RT   (FL-18-EB) obtained from a patient with follicular lymphoma:
RT   monoclonal derivation and different properties.";
RL   Blood 70:1619-1623(1987).
RX   PubMed=3034807; DOI=10.1002/ijc.2910390622;
RA   Ohno H., Fukuhara S., Takahashi R., Mihara K.-i., Sugiyama T., Doi S.,
RA   Uchino H., Toyoshima K.;
RT   "c-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma
RT   cell line carrying a t(14;18) chromosomal translocation.";
RL   Int. J. Cancer 39:785-788(1987).
RX   PubMed=3928551; DOI=10.20772/cancersci1985.76.7_563;
RA   Ohno H., Doi S., Fukuhara S., Nishikori M., Uchino H., Fujii H.;
RT   "A newly established human lymphoma cell line, FL-18, carrying a 14;18
RT   translocation.";
RL   Jpn. J. Cancer Res. 76:563-566(1985).
RX   PubMed=8847894;
RA   Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K.,
RA   Nakamura H., Amakawa R., Ohno H.;
RT   "Sensitivity to dexamethasone and absence of bcl-2 protein in
RT   Burkitt's lymphoma cell line (Black93) derived from a patient with
RT   acute tumor lysis syndrome: comparative study with other BL and non-BL
RT   lines.";
RL   Leukemia 10:1592-1603(1996).
RX   PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x;
RA   Akasaka T., Muramatsu M., Kadowaki N., Ohno H., Ishizaki K.,
RA   Yamabe H., Fukuhara S., Okuma M.;
RT   "p53 mutation in B-cell lymphoid neoplasms with reference to oncogene
RT   rearrangements associated with chromosomal translocations.";
RL   Jpn. J. Cancer Res. 87:930-937(1996).
RX   PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x;
RA   Maesako Y., Uchiyama T., Ohno H.;
RT   "Comparison of gene expression profiles of lymphoma cell lines from
RT   transformed follicular lymphoma, Burkitt's lymphoma and de novo
RT   diffuse large B-cell lymphoma.";
RL   Cancer Sci. 94:774-781(2003).
RX   PubMed=14990977; DOI=10.1038/sj.leu.2403323;
RA   Hardianti M.S., Tatsumi E., Syampurnawati M., Furuta K., Saigo K.,
RA   Nakamachi Y., Kumagai S., Ohno H., Tanabe S., Uchida M., Yasuda N.;
RT   "Activation-induced cytidine deaminase expression in follicular
RT   lymphoma: association between AID expression and ongoing mutation in
RT   FL.";
RL   Leukemia 18:826-831(2004).
RX   PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x;
RA   Kamimura K., Hojo H., Abe M.;
RT   "Characterization of expression of protein kinase C isozymes in human
RT   B-cell lymphoma: relationship between its expression and prognosis.";
RL   Pathol. Int. 54:224-230(2004).
RX   PubMed=26727417; DOI=10.3109/10428194.2015.1108414;
RA   Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for double-hit
RT   B-cell lymphomas.";
RL   Leuk. Lymphoma 57:1015-1020(2016).