ID   FL-18
AC   CVCL_8093
SY   FL18
DR   BTO; BTO_0002518
DR   cancercelllines; CVCL_8093
DR   Cosmic; 2396144
DR   GEO; GSM3150244
DR   IARC_TP53; 5999
DR   PRIDE; PXD012087
DR   Wikidata; Q54834952
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1967982;
RX   PubMed=2822175;
RX   PubMed=3034807;
RX   PubMed=3928551;
RX   PubMed=8847894;
RX   PubMed=8878455;
RX   PubMed=12967475;
RX   PubMed=14990977;
RX   PubMed=15028022;
RX   PubMed=26727417;
CC   Population: Japanese.
CC   Doubling time: 36-48 hours (PubMed=3928551); 25.3 hours (PubMed=8847894).
CC   Sequence variation: Gene fusion; HGNC; HGNC:990; BCL2 + HGNC; HGNC:5477; IGH; Name(s)=IGH-BCL2 (PubMed=12967475).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser127Phe (c.380C>T); ClinVar=VCV000182928; Zygosity=Unspecified (PubMed=8878455).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Misspelling: AKA96-3; IARC_TP53=5999; Note=Not really a misspelling but an assignment of a name based on first author of publication and date because assignment of correct cell line name was not done correctly.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3209; Follicular lymphoma
DI   ORDO; Orphanet_545; Follicular lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_J353 ! FL-18-EB
SX   Male
AG   68Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=3928551; DOI=10.20772/cancersci1985.76.7_563;
RA   Ohno, Hitoshi
RA   Doi, Shoichi
RA   Fukuhara, Shiro
RA   Nishikori, Masaru
RA   Uchino, Haruto
RA   Fujii, Hiroshi
RT   "A newly established human lymphoma cell line, FL-18, carrying a 14;18
RT   translocation.";
RL   Jpn. J. Cancer Res. 76:563-566(1985).
//
RX   PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x;
RA   Kamimura, Katsuhito
RA   Hojo, Hiroshi
RA   Abe, Masafumi
RT   "Characterization of expression of protein kinase C isozymes in human
RT   B-cell lymphoma: relationship between its expression and prognosis.";
RL   Pathol. Int. 54:224-230(2004).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=14990977; DOI=10.1038/sj.leu.2403323;
RA   Hardianti, Mardiah Suci
RA   Tatsumi, Eiji
RA   Syampurnawati, Meilani
RA   Furuta, Kiyoshi
RA   Saigo, Katsuyasu
RA   Nakamachi, Yuji
RA   Kumagai, Shunichi
RA   Ohno, Hitoshi
RA   Tanabe, Satoru
RA   Uchida, M.
RA   Yasuda, Norimasa
RT   "Activation-induced cytidine deaminase expression in follicular
RT   lymphoma: association between AID expression and ongoing mutation in
RT   FL.";
RL   Leukemia 18:826-831(2004).
//
RX   PubMed=8847894;
RA   Tani, Akiyoshi
RA   Tatsumi, Eiji
RA   Nakamura, Fumihiko
RA   Kumagai, Shunichi
RA   Kosaka, Yoshiyuki
RA   Sano, Kimihiko
RA   Nakamura, Hajime
RA   Amakawa, Ryuichi
RA   Ohno, Hitoshi
RT   "Sensitivity to dexamethasone and absence of bcl-2 protein in
RT   Burkitt's lymphoma cell line (Black93) derived from a patient with
RT   acute tumor lysis syndrome: comparative study with other BL and non-BL
RT   lines.";
RL   Leukemia 10:1592-1603(1996).
//
RX   PubMed=26727417; DOI=10.3109/10428194.2015.1108414;
RA   Drexler, Hans Gunther
RA   Eberth, Sonja
RA   Nagel, Stefan
RA   MacLeod, Roderick A.F.
RT   "Malignant hematopoietic cell lines: in vitro models for double-hit
RT   B-cell lymphomas.";
RL   Leuk. Lymphoma 57:1015-1020(2016).
//
RX   PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z;
RA   Nourse, Jamisqn
RA   Mellentin, Julia D.
RA   Galili, Naomi
RA   Wilkinson, Joyce
RA   Stanbridge, Eric John
RA   Smith, Stephen D.
RA   Cleary, Michael L.
RT   "Chromosomal translocation t(1;19) results in synthesis of a homeobox
RT   fusion mRNA that codes for a potential chimeric transcription
RT   factor.";
RL   Cell 60:535-545(1990).
//
RX   PubMed=3034807; DOI=10.1002/ijc.2910390622;
RA   Ohno, Hitoshi
RA   Fukuhara, Shiro
RA   Takahashi, Rei
RA   Mihara, Koh-ichirou
RA   Sugiyama, Taketoshi
RA   Doi, Shoichi
RA   Uchino, Haruto
RA   Toyoshima, Kumao
RT   "c-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma
RT   cell line carrying a t(14;18) chromosomal translocation.";
RL   Int. J. Cancer 39:785-788(1987).
//
RX   PubMed=2822175; DOI=10.1182/blood.V70.5.1619.1619;
RA   Doi, Shoichi
RA   Ohno, Hitoshi
RA   Tatsumi, Eiji
RA   Arita, Yuu
RA   Kamesaki, Hiroshi
RA   Fukuhara, Shiro
RA   Nishikori, Masaru
RA   Miwa, Hiroshi
RA   Kita, Kenkichi
RA   Hatanaka, Masakazu
RA   Honjo, Tasuku
RA   Fujii, Hiroshi
RA   Uchino, Haruto
RT   "Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line
RT   (FL-18-EB) obtained from a patient with follicular lymphoma:
RT   monoclonal derivation and different properties.";
RL   Blood 70:1619-1623(1987).
//
RX   PubMed=8878455; DOI=10.1111/j.1349-7006.1996.tb02122.x; PMCID=PMC5921203;
RA   Akasaka, Takashi
RA   Muramatsu, Mikiko
RA   Kadowaki, Norimitsu
RA   Ohno, Hitoshi
RA   Ishizaki, Kanji
RA   Yamabe, Hirohiko
RA   Fukuhara, Shiro
RA   Okuma, Minoru
RT   "p53 mutation in B-cell lymphoid neoplasms with reference to oncogene
RT   rearrangements associated with chromosomal translocations.";
RL   Jpn. J. Cancer Res. 87:930-937(1996).
//
RX   PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x; PMCID=PMC11160262;
RA   Maesako, Yoshitomo
RA   Uchiyama, Takashi
RA   Ohno, Hitoshi
RT   "Comparison of gene expression profiles of lymphoma cell lines from
RT   transformed follicular lymphoma, Burkitt's lymphoma and de novo
RT   diffuse large B-cell lymphoma.";
RL   Cancer Sci. 94:774-781(2003).
//