• Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=15009714; PubMed=18632627; Wistar).
  

PubMed=2918552; DOI=10.1093/jnci/81.6.440
Dimitrios Iliopoulos, Carolyn S. Ernst, Zenon Steplewski, Jadranka Adriana Jambrosic, Ulrich Rodeck, Meenhard Herlyn, Wallace H. Clark Jr., Hilary Koprowski, Dorothee Herlyn;
Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides.
J. Natl. Cancer Inst. 81:440-444(1989)

PubMed=2156614
Dorothee Herlyn, Dimitrios Iliopoulos, Pamela J. Jensen, Annette Hollister Parmiter, Janet Baird, Hak Hotta, Koji Adachi, Alonzo H. Ross, Jadranka Adriana Jambrosic, Hilary Koprowski, Meenhard Herlyn;
In vitro properties of human melanoma cells metastatic in nude mice.
Cancer Res. 50:2296-2302(1990)

PubMed=2253310; DOI=10.1007/BF00046337
Meenhard Herlyn;
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=8342600; PMCID=PMC1887031
Istvan Juhasz, Steven M. Albelda, David E. Elder, George Francis Murphy, Koji Adachi, Dorothee Herlyn, Istvan T. Valyi-Nagy, Meenhard Herlyn;
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice.
Am. J. Pathol. 143:528-537(1993)

PubMed=15009714; DOI=10.1046/j.0022-202X.2004.22243.x; PMCID=PMC2586668
Hensin Tsao, Vikas Goel, Heng Wu, Guang Yang, Frank G. Haluska;
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
J. Invest. Dermatol. 122:337-341(2004)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer;
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688
Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith Thomas Flaherty, Marcus W. Bosenberg, Meenhard Herlyn, Katherine L. Nathanson;
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431; PMCID=PMC2651569
Keiran S.M. Smalley, Mercedes Lioni, Maurizia Dalla Palma, Min Xiao, Brijal Desai, Suzanne Egyhazi Brage, Johan Hansson, Hong Wu, Alastair J. King, Patricia Van Belle, David E. Elder ...Show all 14 authors... , Keith Thomas Flaherty, Meenhard Herlyn, Katherine L. Nathanson; Show fewer authors
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Mol. Cancer Ther. 7:2876-2883(2008)

PubMed=30380804; DOI=10.3390/molecules23112823; PMCID=PMC6278572
Nadine Kretschmer, Alexander J.A. Deutsch, Christin Durchschein, Beate Rinner, Alexander Stallinger, Juan Carlos Higareda-Almaraz, Marcel Scheideler, Birgit Lohberger, Rudolf Bauer;
Comparative gene expression analysis in WM164 melanoma cells revealed that beta-beta-dimethylacrylshikonin leads to ROS generation, loss of mitochondrial membrane potential, and autophagy induction.
Molecules 23:2823.1-2823.17(2018)

PubMed=34206371; DOI=10.3390/cancers13133111; PMCID=PMC8269360
Ewa Podgorska, Tae-Kang Kim, Zorica Janjetovic, Krystyna Urbanska, Robert C. Tuckey, Sejong Bae, Andrzej Tadeusz Slominski;
Knocking out the vitamin D receptor enhances malignancy and decreases responsiveness to vitamin D3 hydroxyderivatives in human melanoma cells.
Cancers (Basel) 13:3111.1-3111.15(2021)