• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=21156289).
  
• Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=21156289).
  

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023; PMCID=PMC3026446
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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

PubMed=23285177; DOI=10.1371/journal.pone.0052760; PMCID=PMC3532357
Adam B. Schayowitz, Greg P. Bertenshaw, Emiko Jeffries, Timothy Schatz, James Cotton, Jessie Villanueva, Meenhard Herlyn, Clemens Krepler, Adina Vultur, Wei Xu, Gordon H. Yu ...Show all 13 authors... , Lynn Mara Schuchter, Douglas P. Clark; Show fewer authors
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:e52760.1-e52760.8(2012)

PubMed=24055054; DOI=10.1016/j.celrep.2013.08.023; PMCID=PMC3956616
Jessie Villanueva, Jeffrey R. Infante, Clemens Krepler, Patricia Reyes-Uribe, Minu Samanta, Hsin-Yi Chen, Bin Li, Rolf K. Swoboda, Melissa Wilson, Adina Vultur, Mizuho Fukunaga-Kalabis ...Show all 28 authors... , Bradley Wubbenhorst, Thomas Y. Chen, Qin Liu, Katrin Sproesser, Douglas J. DeMarini, Tona Morgan Gilmer, Anne-Marie Martin, Ronen Marmorstein, David C. Schultz, David W. Speicher, Giorgos Constantine Karakousis, Wei Xu, Ravi K. Amaravadi, Xiao-Wei Xu, Lynn Mara Schuchter, Meenhard Herlyn, Katherine L. Nathanson; Show fewer authors
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma.
Cell Rep. 4:1090-1099(2013)