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Cellosaurus WM164 VDR KO (CVCL_B6Q1)

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Cell line name WM164 VDR KO
Synonyms VDR KO WM164
Accession CVCL_B6Q1
Resource Identification Initiative To cite this cell line use: WM164 VDR KO (RRID:CVCL_B6Q1)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:12679; VDR.
Derived from site: Metastatic; Arm, skin; UBERON=UBERON_0002427.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7928 (WM164)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
Publications

PubMed=34206371; DOI=10.3390/cancers13133111; PMCID=PMC8269360
Ewa Podgorska, Tae-Kang Kim, Zorica Janjetovic, Krystyna Urbanska, Robert C. Tuckey, Sejong Bae, Andrzej Tadeusz Slominski;
Knocking out the vitamin D receptor enhances malignancy and decreases responsiveness to vitamin D3 hydroxyderivatives in human melanoma cells.
Cancers (Basel) 13:3111.1-3111.15(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B6Q1
Encyclopedic resources Wikidata; Q112041937
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number6