Cellosaurus cell line SYO-1 (CVCL

Cellosaurus SYO-1 (CVCL_7146)

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Cell line name

SYO-1

Synonyms

SYO-I; SYO1

Accession

CVCL_7146

Resource Identification Initiative

To cite this cell line use: SYO-1 (RRID:CVCL_7146)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 28 hours (PubMed=14744540).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Miscellaneous: STR profile from personal communication of Duan, Zhen-Feng through ICLAC.
Derived from site: In situ; Groin; UBERON=UBERON_0008337.

Sequence variations

Gene fusion; HGNC; HGNC:11340; SS18 + HGNC; HGNC:11336; SSX2; Name(s)=SS18-SSX2 (PubMed=14744540; DepMap=ACH-001275).
Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Unspecified (DepMap=ACH-001275).

Disease

Biphasic synovial sarcoma (NCIt: C4279)
Synovial sarcoma (ORDO: Orphanet_3273)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_ZV94 (OSA 1777)

Sex of cell

Female

Age at sampling

19Y

Category

Cancer cell line

STR profile

Source(s): ICLAC

Markers:

Amelogenin	X
CSF1PO	10
D3S1358	15
D5S818	9,12
D7S820	11
D8S1179	12,24
D13S317	9
D16S539	9,13
D18S51	15,19
D21S11	30
FGA	19,24
Penta D	9,12
Penta E	5,15
TH01	6,7
TPOX	9,12
vWA	17

Publications

PubMed=14744540; DOI=10.1016/j.canlet.2003.09.031
Akira Kawai, Noriko Naito, Aki Yoshida, Yuki Morimoto, Mamoru Ouchida, Kenji Shimizu, Yasuo Beppu;
Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1.
Cancer Lett. 204:105-113(2004)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27353471; DOI=10.1111/gtc.12387
Hiroyuki Yamasaki, Mamiko Miyamoto, Yuki Yamamoto, Tadashi Kondo, Toshiki Watanabe, Tsutomu Ohta;
Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor.
Genes Cells 21:852-860(2016)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_7146
Cell_Model_Passport; SIDM01453
DepMap; ACH-001275

Chemistry resources

PharmacoDB; SYO1_1553_2019

Encyclopedic resources

Wikidata; Q54971281

Experimental variables resources

EFO; EFO_0022505

Gene expression databases

GEO; GSM482570
GEO; GSM1676335
GEO; GSM1701667
GEO; GSM2887622
GEO; GSM2887623

Polymorphism and mutation databases