ID   SYO-1
AC   CVCL_7146
SY   SYO-I; SYO1
DR   EFO; EFO_0022505
DR   cancercelllines; CVCL_7146
DR   Cell_Model_Passport; SIDM01453
DR   Cosmic; 1211854
DR   Cosmic; 1319812
DR   Cosmic; 2307725
DR   DepMap; ACH-001275
DR   GEO; GSM482570
DR   GEO; GSM1676335
DR   GEO; GSM1701667
DR   GEO; GSM2887622
DR   GEO; GSM2887623
DR   PharmacoDB; SYO1_1553_2019
DR   Progenetix; CVCL_7146
DR   Wikidata; Q54971281
RX   PubMed=14744540;
RX   PubMed=24726063;
RX   PubMed=26351324;
RX   PubMed=27353471;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 28 hours (PubMed=14744540).
CC   Sequence variation: Gene fusion; HGNC; HGNC:11340; SS18 + HGNC; HGNC:11336; SSX2; Name(s)=SS18-SSX2 (PubMed=14744540; DepMap=ACH-001275).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Unspecified (DepMap=ACH-001275).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Miscellaneous: STR profile from personal communication of Duan, Zhen-Feng through ICLAC.
CC   Derived from site: In situ; Groin; UBERON=UBERON_0008337.
ST   Source(s): ICLAC
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 9
ST   D16S539: 9,13
ST   D18S51: 15,19
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 9,12
ST   D7S820: 11
ST   D8S1179: 12,24
ST   FGA: 19,24
ST   Penta D: 9,12
ST   Penta E: 5,15
ST   TH01: 6,7
ST   TPOX: 9,12
ST   vWA: 17
DI   NCIt; C4279; Biphasic synovial sarcoma
DI   ORDO; Orphanet_3273; Synovial sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   19Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 28
CH   CVCL_ZV94 ! OSA 1777
//
RX   PubMed=27353471; DOI=10.1111/gtc.12387;
RA   Yamasaki, Hiroyuki
RA   Miyamoto, Mamiko
RA   Yamamoto, Yuki
RA   Kondo, Tadashi
RA   Watanabe, Toshiki
RA   Ohta, Tsutomu
RT   "Synovial sarcoma cell lines showed reduced DNA repair activity and
RT   sensitivity to a PARP inhibitor.";
RL   Genes Cells 21:852-860(2016).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher, Beverly A.
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Monks, Anne
RA   Morris, Joel
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=14744540; DOI=10.1016/j.canlet.2003.09.031;
RA   Kawai, Akira
RA   Naito, Noriko
RA   Yoshida, Aki
RA   Morimoto, Yuki
RA   Ouchida, Mamoru
RA   Shimizu, Kenji
RA   Beppu, Yasuo
RT   "Establishment and characterization of a biphasic synovial sarcoma
RT   cell line, SYO-1.";
RL   Cancer Lett. 204:105-113(2004).
//
RX   PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359;
RA   Koelsche, Christian
RA   Renner, Marcus
RA   Hartmann, Wolfgang
RA   Brandt, Regine
RA   Lehner, Burkhard
RA   Waldburger, Nina
RA   Alldinger, Ingo
RA   Schmitt, Thomas
RA   Egerer, Gerlinde
RA   Penzel, Roland
RA   Wardelmann, Eva
RA   Schirmacher, Peter
RA   von Deimling, Andreas
RA   Mechtersheimer, Gunhild
RT   "TERT promoter hotspot mutations are recurrent in myxoid liposarcomas
RT   but rare in other soft tissue sarcoma entities.";
RL   J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014).
//