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Cellosaurus PC-3 ML (CVCL_6E90)

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Cell line name PC-3 ML
Synonyms PC3-ML; PC-3 Metastasis in Lumbar vertebrae
Accession CVCL_6E90
Resource Identification Initiative To cite this cell line use: PC-3 ML (RRID:CVCL_6E90)
Comments Population: Caucasian.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Children:
CVCL_ZC63 (PC-3 ML-Luc)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=1773917; DOI=10.1111/j.1432-0436.1991.tb00250.x
Min Wang, Mark E. Stearns;
Isolation and characterization of PC-3 human prostatic tumor sublines which preferentially metastasize to select organs in S.C.I.D. mice.
Differentiation 48:115-125(1991)

PubMed=1352184
Mark E. Stearns, Min Wang;
Taxol blocks processes essential for prostate tumor cell (PC-3 ML) invasion and metastases.
Cancer Res. 52:3776-3781(1992)

PubMed=22275356; DOI=10.1074/jbc.M111.302547; PMCID=PMC3322861
Thomas P. Lynch, Christina M. Ferrer, S. RaElle Jackson, Kristina S. Shahriari, Keith Vosseller, Mauricio J. Reginato;
Critical role of O-linked beta-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.
J. Biol. Chem. 287:11070-11081(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6E90
Anatomy/cell type resources BTO; BTO_0006369
Encyclopedic resources Wikidata; Q54938411
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number13