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Cellosaurus IPEC-J2 MDR1 (CVCL_6C41)

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Cell line name IPEC-J2 MDR1
Synonyms iP-gp
Accession CVCL_6C41
Resource Identification Initiative To cite this cell line use: IPEC-J2 MDR1 (RRID:CVCL_6C41)
Comments Characteristics: Can be used to screen drug compounds for interactions with human efflux pump P-glycoprotein (P-gp) (PubMed=26651362).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:40; ABCB1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Small intestine, jejunum; UBERON=UBERON_0002115.
Cell type: Enterocyte; CL=CL_0000584.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Hierarchy Parent: CVCL_2246 (IPEC-J2)
Sex of cell Sex unspecified
Age at sampling <1D
Category Spontaneously immortalized cell line
Publications

PubMed=26651362; DOI=10.1021/acs.molpharmaceut.5b00874
Lasse Saaby, Hans Christian Cederberg Helms, Birger Brodin;
IPEC-J2 MDR1, a novel high-resistance cell line with functional expression of human P-glycoprotein (ABCB1) for drug screening studies.
Mol. Pharm. 13:640-652(2016)

PubMed=29146563; DOI=10.1016/j.ejps.2017.11.007
Burak Ozgur, Lasse Saaby, Kristine Langthaler, Birger Brodin;
Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates.
Eur. J. Pharm. Sci. 112:112-121(2018)

Cross-references
Encyclopedic resources Wikidata; Q54897970
Entry history
Entry creation23-Feb-2016
Last entry update14-Aug-2025
Version number12