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Cellosaurus IPEC-J2 MDR1 (CVCL_6C41)

[Text version]
Cell line name IPEC-J2 MDR1
Accession CVCL_6C41
Resource Identification Initiative To cite this cell line use: IPEC-J2 MDR1 (RRID:CVCL_6C41)
Comments Characteristics: Can be used to screen drug compounds for interactions with human efflux pump P-glycoprotein (P-gp).
Transfected with: HGNC; 40; ABCB1.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Small intestine, jejunum; UBERON=UBERON_0002115.
Cell type: Enterocyte; CL=CL_0000584.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Hierarchy Parent: CVCL_2246 (IPEC-J2)
Sex of cell Sex unspecified
Age at sampling <1D
Category Spontaneously immortalized cell line
Web pages http://healthsciences.ku.dk/news/new-2016/copenhagen-researchers-develop-novel-cell-line-for-screening-of-brain-drugs/

PubMed=26651362; DOI=10.1021/acs.molpharmaceut.5b00874
Saaby L., Helms H.C.C., Brodin B.
IPEC-J2 MDR1, a novel high-resistance cell line with functional expression of human P-glycoprotein (ABCB1) for drug screening studies.
Mol. Pharm. 13:640-652(2016)

Encyclopedic resources Wikidata; Q54897970
Entry history
Entry creation23-Feb-2016
Last entry update29-Jun-2023
Version number8