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Cellosaurus MDA-686Ln (CVCL_6984)

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Cell line name MDA-686Ln
Synonyms MDA 686Ln; MDA686Ln; MDA686LN; MDA 686LN; MDA 686-LN; MDA 686 Ln; 686LN; 686Ln
Accession CVCL_6984
Resource Identification Initiative To cite this cell line use: MDA-686Ln (RRID:CVCL_6984)
Comments Problematic cell line: Partially contaminated. Some stocks are contaminated by UM-SCC-1 (PubMed=21868764).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00442.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Oropharyngeal squamous cell carcinoma (NCIt: C8181)
Squamous cell carcinoma of the oropharynx (ORDO: Orphanet_500478)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D099 (686LN-M3e)CVCL_D097 (686LN-M4e)CVCL_D098 (686LN-R30)
Originate from same individual CVCL_6983 ! MDA-686
CVCL_6985 ! MDA-686Tu
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO12
D5S81812
D7S82010
D13S31712
D16S5398,9
TH017,8
TPOX10,11
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=7927946; DOI=10.1002/ijc.2910590316
Li Xu, Bruce J. Davidson, Vundavalli V.V.S. Murty, Rong-Guo Li, Peter G. Sacks, Pilar Garin-Chesa, Stimson P. Schantz, Raju S.K. Chaganti;
TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.
Int. J. Cancer 59:383-387(1994)

PubMed=14724901; DOI=10.1002/hed.10344
Volkert Boudewijn Wreesmann, Dorothy Wang, Andy Goberdhan, Mukesh Prasad, Ivan Ngai, Erik A. Schnaser, Peter G. Sacks, Bhuvanesh Singh;
Genetic abnormalities associated with nodal metastasis in head and neck cancer.
Head Neck 26:10-15(2004)

PubMed=15641986; DOI=10.1111/j.1600-0714.2004.00258.x
Nadarajah Vigneswaran, Jean Wu, Peter G. Sacks, Michael Gilcrease, Wolfgang Zacharias;
Microarray gene expression profiling of cell lines from primary and metastatic tongue squamous cell carcinoma: possible insights from emerging technology.
J. Oral Pathol. Med. 34:77-86(2005)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6984
Anatomy/cell type resources BTO; BTO_0003052
Encyclopedic resources Wikidata; Q54904562
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28