ID   MDA-686Ln
AC   CVCL_6984
SY   MDA 686Ln; MDA686Ln; MDA686LN; MDA 686LN; MDA 686-LN; MDA 686 Ln; 686LN; 686Ln
DR   BTO; BTO_0003052
DR   cancercelllines; CVCL_6984
DR   Wikidata; Q54904562
RX   PubMed=7927946;
RX   PubMed=14724901;
RX   PubMed=15641986;
RX   PubMed=21868764;
RX   PubMed=26754630;
RX   PubMed=29156801;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Partially contaminated. Some stocks are contaminated by UM-SCC-1 (PubMed=21868764).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00442.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Unspecified (PubMed=7927946).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 8,9
ST   D5S818: 12
ST   D7S820: 10
ST   TH01: 7,8
ST   TPOX: 10,11
ST   vWA: 15,16
DI   NCIt; C8181; Oropharyngeal squamous cell carcinoma
DI   ORDO; Orphanet_500478; Squamous cell carcinoma of the oropharynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_6983 ! MDA-686
OI   CVCL_6985 ! MDA-686Tu
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
CH   CVCL_D099 ! 686LN-M3e
CH   CVCL_D097 ! 686LN-M4e
CH   CVCL_D098 ! 686LN-R30
//
RX   PubMed=7927946; DOI=10.1002/ijc.2910590316;
RA   Xu, Li
RA   Davidson, Bruce J.
RA   Murty, Vundavalli V.V.S.
RA   Li, Rong-Guo
RA   Sacks, Peter G.
RA   Garin-Chesa, Pilar
RA   Schantz, Stimson P.
RA   Chaganti, Raju S.K.
RT   "TP53 gene mutations and CCND1 gene amplification in head and neck
RT   squamous cell carcinoma cell lines.";
RL   Int. J. Cancer 59:383-387(1994).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939;
RA   Hyakusoku, Hiroshi
RA   Sano, Daisuke
RA   Takahashi, Hideaki
RA   Hatano, Takashi
RA   Isono, Yasuhiro
RA   Shimada, Shoko
RA   Ito, Yusuke
RA   Myers, Jeffrey N.
RA   Oridate, Nobuhiko
RT   "JunB promotes cell invasion, migration and distant metastasis of head
RT   and neck squamous cell carcinoma.";
RL   J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
//
RX   PubMed=14724901; DOI=10.1002/hed.10344;
RA   Wreesmann, Volkert Boudewijn
RA   Wang, Dorothy
RA   Goberdhan, Andy
RA   Prasad, Mukesh
RA   Ngai, Ivan
RA   Schnaser, Erik A.
RA   Sacks, Peter G.
RA   Singh, Bhuvanesh
RT   "Genetic abnormalities associated with nodal metastasis in head and
RT   neck cancer.";
RL   Head Neck 26:10-15(2004).
//
RX   PubMed=15641986; DOI=10.1111/j.1600-0714.2004.00258.x;
RA   Vigneswaran, Nadarajah
RA   Wu, Jean
RA   Sacks, Peter G.
RA   Gilcrease, Michael
RA   Zacharias, Wolfgang
RT   "Microarray gene expression profiling of cell lines from primary and
RT   metastatic tongue squamous cell carcinoma: possible insights from
RT   emerging technology.";
RL   J. Oral Pathol. Med. 34:77-86(2005).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//