ID   MDA-686Ln
AC   CVCL_6984
SY   MDA 686Ln; MDA686Ln; MDA686LN; MDA 686LN; MDA 686-LN; MDA 686 Ln; 686LN; 686Ln
DR   BTO; BTO:0003052
DR   cancercelllines; CVCL_6984
DR   Wikidata; Q54904562
RX   PubMed=7927946;
RX   PubMed=14724901;
RX   PubMed=15641986;
RX   PubMed=21868764;
RX   PubMed=26754630;
RX   PubMed=29156801;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Partially contaminated. Some stocks are contaminated by UM-SCC-1 (PubMed=21868764).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00442.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Unspecified (PubMed=7927946).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 8,9
ST   D5S818: 12
ST   D7S820: 10
ST   TH01: 7,8
ST   TPOX: 10,11
ST   vWA: 15,16
DI   NCIt; C8181; Oropharyngeal squamous cell carcinoma
DI   ORDO; Orphanet_500478; Squamous cell carcinoma of the oropharynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_6983 ! MDA-686
OI   CVCL_6985 ! MDA-686Tu
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 26
//
RX   PubMed=7927946; DOI=10.1002/ijc.2910590316;
RA   Xu L., Davidson B.J., Murty V.V.V.S., Li R.-G., Sacks P.G.,
RA   Garin-Chesa P., Schantz S.P., Chaganti R.S.K.;
RT   "TP53 gene mutations and CCND1 gene amplification in head and neck
RT   squamous cell carcinoma cell lines.";
RL   Int. J. Cancer 59:383-387(1994).
//
RX   PubMed=14724901; DOI=10.1002/hed.10344;
RA   Wreesmann V.B., Wang D., Goberdhan A., Prasad M., Ngai I.,
RA   Schnaser E.A., Sacks P.G., Singh B.;
RT   "Genetic abnormalities associated with nodal metastasis in head and
RT   neck cancer.";
RL   Head Neck 26:10-15(2004).
//
RX   PubMed=15641986; DOI=10.1111/j.1600-0714.2004.00258.x;
RA   Vigneswaran N., Wu J., Sacks P.G., Gilcrease M., Zacharias W.;
RT   "Microarray gene expression profiling of cell lines from primary and
RT   metastatic tongue squamous cell carcinoma: possible insights from
RT   emerging technology.";
RL   J. Oral Pathol. Med. 34:77-86(2005).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939;
RA   Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S.,
RA   Ito Y., Myers J.N., Oridate N.;
RT   "JunB promotes cell invasion, migration and distant metastasis of head
RT   and neck squamous cell carcinoma.";
RL   J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//