Cellosaurus logo
expasy logo

Cellosaurus MDA-686Tu (CVCL_6985)

[Text version]
Cell line name MDA-686Tu
Synonyms MDA 686Tu; MDA686Tu; MDA686TU; 686TU; 686Tu
Accession CVCL_6985
Resource Identification Initiative To cite this cell line use: MDA-686Tu (RRID:CVCL_6985)
Comments Problematic cell line: Partially contaminated. Some stocks are contaminated by T404/T406/Tu 1387Tu 158LN/Tu 159/Tu 182/Tu 212/Tu 212LN (PubMed=21868764).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00443.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Unspecified (PubMed=7927946).
Disease Oropharyngeal squamous cell carcinoma (NCIt: C8181)
Squamous cell carcinoma of the oropharynx (ORDO: Orphanet_500478)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_6983 ! MDA-686
CVCL_6984 ! MDA-686Ln
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=7927946; DOI=10.1002/ijc.2910590316
Xu L., Davidson B.J., Murty V.V.V.S., Li R.-G., Sacks P.G., Garin-Chesa P., Schantz S.P., Chaganti R.S.K.
TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.
Int. J. Cancer 59:383-387(1994)

PubMed=14724901; DOI=10.1002/hed.10344
Wreesmann V.B., Wang D., Goberdhan A., Prasad M., Ngai I., Schnaser E.A., Sacks P.G., Singh B.
Genetic abnormalities associated with nodal metastasis in head and neck cancer.
Head Neck 26:10-15(2004)

PubMed=15641986; DOI=10.1111/j.1600-0714.2004.00258.x
Vigneswaran N., Wu J., Sacks P.G., Gilcrease M., Zacharias W.
Microarray gene expression profiling of cell lines from primary and metastatic tongue squamous cell carcinoma: possible insights from emerging technology.
J. Oral Pathol. Med. 34:77-86(2005)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cell line databases/resources cancercelllines; CVCL_6985
Encyclopedic resources Wikidata; Q54904563
Polymorphism and mutation databases IARC_TP53; 3550
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number20