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Cellosaurus WM239A (CVCL_6795)

[Text version]
Cell line name WM239A
Synonyms WM-239A; WM-239-A; WM 239-A; WM 239A; WM-239; WM239; WM 239; WC00044
Accession CVCL_6795
Resource Identification Initiative To cite this cell line use: WM239A (RRID:CVCL_6795)
Comments Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (Wistar).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (Wistar).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Hemizygous (Wistar).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Asp (c.1799_1800delTGinsAT); ClinVar=VCV000375939; Zygosity=Heterozygous (PubMed=15009714; Wistar).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VS31 (WM239A HmR)
Originate from same individual CVCL_0040 ! WM115
CVCL_L033 ! WM165-1
CVCL_RN55 ! WM165-2
CVCL_RN56 ! WM239B
CVCL_RN57 ! WM266-1
CVCL_RN58 ! WM266-2
CVCL_RN59 ! WM266-3
CVCL_2765 ! WM266-4
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): Wistar

Markers:
AmelogeninX
CSF1PO11,12
D5S81812,13
D7S8207,8
D13S31711,12
D16S53911,12
D21S1128,29
TH017,9
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=3856042; DOI=10.1093/jnci/74.2.283
Meenhard Herlyn, Gloria Brady Balaban-Malenbaum, Jeannette L. Bennicelli, DuPont Guerry 4th, Ruth Halaban, Dorothee Herlyn, David E. Elder, Gerd G. Maul, Zenon Steplewski, Peter Carey Nowell, Wallace H. Clark Jr., Hilary Koprowski;
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.
J. Natl. Cancer Inst. 74:283-289(1985)

PubMed=4053039
Meenhard Herlyn, Jan Thurin, Gloria Brady Balaban-Malenbaum, Jeannette L. Bennicelli, Dorothee Herlyn, David E. Elder, Edward Bondi, DuPont Guerry 4th, Peter Carey Nowell, Wallace H. Clark Jr., Hilary Koprowski;
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Cancer Res. 45:5670-5676(1985)

PubMed=3020539; DOI=10.1073/pnas.83.19.7197; PMCID=PMC386682
Bengt Westermark, Anders Johnsson, Ylva Paulsson, Christer Betsholtz, Carl-Henrik Heldin, Meenhard Herlyn, Ulrich Rodeck, Hilary Koprowski;
Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.
Proc. Natl. Acad. Sci. U.S.A. 83:7197-7200(1986)

PubMed=2253310; DOI=10.1007/BF00046337
Meenhard Herlyn;
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=15009714; DOI=10.1046/j.0022-202X.2004.22243.x; PMCID=PMC2586668
Hensin Tsao, Vikas Goel, Heng Wu, Guang Yang, Frank G. Haluska;
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
J. Invest. Dermatol. 122:337-341(2004)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer;
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688
Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith Thomas Flaherty, Marcus W. Bosenberg, Meenhard Herlyn, Katherine L. Nathanson;
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

Cross-references
Cell line collections (Providers) Coriell; WC00044 - Discontinued
Rockland; WM239A-01-0001
Cell line databases/resources cancercelllines; CVCL_6795
Cell_Model_Passport; SIDM00978
Anatomy/cell type resources BTO; BTO_0003474
Chemistry resources GDSC; 1240225
PharmacoDB; WM239A_1670_2019
Encyclopedic resources Wikidata; Q54994215
Gene expression databases GEO; GSM109034
GEO; GSM188232
GEO; GSM188262
GEO; GSM188321
Polymorphism and mutation databases Cosmic; 888850
Cosmic; 928690
Cosmic; 972260
Cosmic; 1155288
Cosmic; 1155564
Cosmic; 1303069
Cosmic; 1477413
IARC_TP53; 24993
Progenetix; CVCL_6795
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30