Cellosaurus logo
expasy logo

Cellosaurus 4-1.10 (CVCL_6546)

[Text version]
Cell line name 4-1.10
Synonyms 4-1.10''
Accession CVCL_6546
Resource Identification Initiative To cite this cell line use: 4-1.10 (RRID:CVCL_6546)
Comments Population: Caucasian.
Characteristics: Selected to be resistant to the anti proliferative effects of oncostatin.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=4-1.10

McDonald V.L., Dick K.O., Malik N., Shoyab M.
Selection and characterization of a variant of human melanoma cell line, A375 resistant to growth inhibitory effects of oncostatin M (OM): coresistant to interleukin 6 (IL-6).
Growth Factors 9:167-175(1993)

Cell line databases/resources cancercelllines; CVCL_6546
Encyclopedic resources Wikidata; Q54602838
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22