ID   4-1.10
AC   CVCL_6546
SY   4-1.10''
DR   cancercelllines; CVCL_6546
DR   Wikidata; Q54602838
RX   PubMed=8274294;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=4-1.10
CC   Population: Caucasian.
CC   Characteristics: Selected to be resistant to the anti proliferative effects of oncostatin.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
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RX   PubMed=8274294;
RA   McDonald V.L., Dick K.O., Malik N., Shoyab M.;
RT   "Selection and characterization of a variant of human melanoma cell
RT   line, A375 resistant to growth inhibitory effects of oncostatin M
RT   (OM): coresistant to interleukin 6 (IL-6).";
RL   Growth Factors 9:167-175(1993).
//