Cell line name |
J.gamma1 |
Synonyms |
Jgamma1; Jurkat Gamma1 |
Accession |
CVCL_6410 |
Resource Identification Initiative |
To cite this cell line use: J.gamma1 (RRID:CVCL_6410) |
Comments |
Population: Caucasian. Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191). Omics: Proteomics; PTM; Phosphorylation. Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0367 (Jurkat E6.1) Children:
|
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC=CRL-2678
Markers:Amelogenin | X |
CSF1PO | 11,12 |
D2S1338 | 18,23 |
D3S1358 | 15,17 |
D5S818 | 9 |
D7S820 | 8,12 |
D8S1179 | 13,14 |
D13S317 | 8,12 |
D16S539 | 11 |
D18S51 | 13,20 |
D19S433 | 14,15.2 |
D21S11 | 31.2,35.2 |
FGA | 20,21 |
Penta D | 10,13 |
Penta E | 10,12 |
TH01 | 6,9.3 |
TPOX | 8,10 |
vWA | 18,19 |
Run an STR similarity search on this cell line |
Publications | PubMed=11094067; DOI=10.1128/mcb.20.24.9149-9161.2000; PMCID=PMC102173 Brenda J. Irvin, Brandi L. Williams, Allan Edward Nilson, Hannah O. Maynor, Robert T. Abraham; Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol. Cell. Biol. 20:9149-9161(2000) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) PubMed=26546556; DOI=10.1016/j.jprot.2015.10.029 Tien Dung Nguyen, Montserrat Carrascal, Oriol Vidal-Cortes, Oscar Gallardo, Vanessa Casas, Marina Gay, Van Chi Phan, Joaquin Abian; The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies. J. Proteomics 131:190-198(2016) |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-2678
|
Cell line databases/resources |
CLO; CLO_0006985
CLO; CLO_0009836
cancercelllines; CVCL_6410
LINCS_LDP; LCL-2038
|
Biological sample resources |
BioSample; SAMN03471763
|
Encyclopedic resources |
Wikidata; Q54898430
|
Gene expression databases |
GEO; GSM827148
|
Polymorphism and mutation databases |
Progenetix; CVCL_6410
|
Proteomic databases |
PRIDE; PXD002871
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 10-Apr-2025 |
Version number | 32 |
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