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Cellosaurus J.gamma1.WT (CVCL_6411)

[Text version]
Cell line name J.gamma1.WT
Synonyms J.gamma1.WT-1; J.gamma1.wt
Accession CVCL_6411
Resource Identification Initiative To cite this cell line use: J.gamma1.WT (RRID:CVCL_6411)
Comments Population: Caucasian.
Transfected with: HGNC; 9065; PLCG1.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6410 (J.gamma1)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2679

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,23
D3S135815,17
D5S8189
D7S8208,12
D8S117913,14
D13S3178,12
D16S53911
D18S5113,20
D19S43314,15.2
D21S1131.2,35.2
FGA20,21
Penta D10,13
Penta E10,12
TH016,9.3
TPOX8,9,10
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=11094067; DOI=10.1128/mcb.20.24.9149-9161.2000
Irvin B.J., Williams B.L., Nilson A.E., Maynor H.O., Abraham R.T.
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Mol. Cell. Biol. 20:9149-9161(2000)

Cross-references
Cell line collections (Providers) ATCC; CRL-2679
Cell line databases/resources CLO; CLO_0006986
CLO; CLO_0009837
cancercelllines; CVCL_6411
LINCS_LDP; LCL-2039
Biological sample resources BioSample; SAMN03471764
Encyclopedic resources Wikidata; Q54898431
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number30